Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder.

ABSTRACT:

Background

Controllability analysis is an approach developed for evaluating the ability of a brain region to modulate function in other regions, which has been found to be altered in major depressive disorder (MDD). Both depressive symptoms and cognitive impairments are prominent features of MDD, but the case-control differences of controllability between MDD and controls can not fully interpret the contribution of both clinical symptoms and cognition to brain controllability and linked patterns among them in MDD.

Methods

Sparse canonical correlation analysis was used to investigate the associations between resting-state functional brain controllability at the network level and clinical symptoms and cognition in 99 first-episode medication-naïve patients with MDD.

Finding

SUBMITTER: Li Q 

PROVIDER: S-EPMC11324849 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature