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TranscriptomicsExpression and regulation of lincRNAs during T cell development and differentiation
Although lincRNAs are implicated in regulating gene expression in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identify 1,524 lincRNAs in 42 T cell samples from early T cell progenitors to terminally differentiated T helper subsets. Our analysis revea...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-48138 | biostudies-arrayexpress
TranscriptomicsKDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation [RNA-Seq]
Pluripotency of embryonic stem (ES) cells is controlled in part by chromatin-modifying factors that regulate histone H3 lysine 4 (H3K4) methylation. However, it remains unclear how H3K4 demethylation contributes to ES cell function. Here, we show that KDM5B, which demethylates lysine 4 of histone H3...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-53090 | biostudies-arrayexpress
GenomicsKDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation [ChIP-Seq]
Pluripotency of embryonic stem (ES) cells is controlled in part by chromatin-modifying factors that regulate histone H3 lysine 4 (H3K4) methylation. However, it remains unclear how H3K4 demethylation contributes to ES cell function. Here, we show that KDM5B, which demethylates lysine 4 of histone H3...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-53087 | biostudies-arrayexpress
TranscriptomicsExtended self-renewal and accelerated reprogramming in the absence of Kdm5b
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-10-14 | E-GEOD-46893 | biostudies-arrayexpress
GenomicsExtended self-renewal and accelerated reprogramming in the absence of Kdm5b [ChIP-Seq]
ES cell pluripotency is thought to be regulated in part by H3K4 methylation. However, it is unclear how H3K4 demethylation contributes to ES cell function and participates in iPS cell reprogramming. Here, we show that KDM5B, which demethylates H3K4, is important for ES cell differentiation, and pres...
ORGANISM(S): Mus musculus 
2013-10-14 | E-GEOD-47123 | biostudies-arrayexpress
TranscriptomicsExtended self-renewal and accelerated reprogramming in the absence of Kdm5b [RNA-Seq]
ES cell pluripotency is thought to be regulated in part by H3K4 methylation. However, it is unclear how H3K4 demethylation contributes to ES cell function and participates in iPS cell reprogramming. Here, we show that KDM5B, which demethylates H3K4, is important for ES cell differentiation, and pres...
ORGANISM(S): Mus musculus 
2013-10-14 | E-GEOD-47124 | biostudies-arrayexpress
TranscriptomicsNegative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging (microarray expression)
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important rol...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-54436 | biostudies-arrayexpress
TranscriptomicsRegulation of pluripotency and self-renewal of ES cells through epigenetic-threshold modulation and mRNA pruning
The core pluripotency factors (Oct4, Sox2, and Nanog), the Myc network, and the chromatin-modifying complexes such as PRC2 ensure the pluripotency and self-renewal of ES cells (ESC). How these factors coordinate with one another remains poorly understood. We report that Utf1, a target of Oct4 and So...
ORGANISM(S): Mus musculus 
2012-10-26 | E-GEOD-39513 | biostudies-arrayexpress
Transcriptomicsc-Myc is a universal amplifier of gene expression [Microarray]
The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism and differentiation at the cellular, tissue or organismal levels via regulation of numerous target genes. In part due to the incomplete inventory and functional accounting of ...
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-37222 | biostudies-arrayexpress
TranscriptomicsRegulation of nucleosome landscape and transcription factor binding at enhancers by BRG1
Enhancers of transcription activate transcription via binding of sequence-specific transcription factors to their target sites in chromatin. In this report, we identify GATA1-bound enhancers genome-wide and find a global reorganization of the nucleosomes at these enhancers during differentiation of ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-26501 | biostudies-arrayexpress
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