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ProteomicsDnj4HA AP-MS in Cryptococcus neoformans
Proteins which act as histone chaperones ensure genomic integrity during routine processes such as DNA replication and transcription as well as DNA repair upon damage. Herein, we identify a nuclear J domain protein, Dnj4, which interacts with histones 3 and 4 as well as Hsp71 as demonstrated in an A...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2021-12-15 | PXD028087 | Pride
Histone Co-chaperone Cryptococcus neoformans J domain protein 
TranscriptomicsHapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
Analysis of the transcriptional response of C. neoformans WT, cir1 mutant, hap3 mutant and hapX mutant to different iron sources. The following experimental design was adopted for the study. Within each strain, each treatment pair (low-iron, +FeCl3, +Transferrin and +Hemin; 6 pairs) were hybridized ...
ORGANISM(S): Cryptococcus neoformans 
2011-04-13 | E-GEOD-22988 | biostudies-arrayexpress
ProteomicsMultisystems analysis of Mycobacterium tuberculosis reveals kinase-dependent remodeling of the pathogen-environment interface
Tuberculosis is the leading killer among infectious diseases worldwide. The rise of multi-drug resistance has prompted new approaches for tuberculosis drug development, including inhibition of virulence determinants and of signaling cascades that control many downstream pathways. Here we used a mult...
ORGANISM(S): Mycobacterium tuberculosis 
2018-03-09 | PXD008968 | Pride
Dia Proteomics Phosphoproteomics Systems biology Dda 
UnknownPerformance of Two Trichogrammatid Species from Zambia on Fall Armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae).
Not available
S-EPMC8538588 | biostudies-literature
UnknownProtocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial.
Not available
S-EPMC12810988 | biostudies-literature
TranscriptomicsBortezomib resistance in THP-1 cell line
Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the THP-1 monocytic/macrophage cell line. On th...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-11771 | biostudies-arrayexpress
ProteomicsMrj1HA AP-MS in Cryptococcus neoformans
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence. In this study, we identified a novel mitochondrial co-chaperone, Mrj...
ORGANISM(S): Cryptococcus neoformans var. grubii H99S 
2020-06-12 | PXD013659 | Pride
Cryptococcus neoformans 
UnknownRenalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma.
Not available
S-EPMC8480607 | biostudies-literature
UnknownSafety and clinical efficacy of Relmacabtagene autoleucel (relma-cel) for systemic lupus erythematosus: a phase 1 open-label clinical trial.
Not available
S-EPMC12083988 | biostudies-literature
MetabolomicsMetabolic plasticity confers increased resilience to climate variability in temperate compared to tropical lizards

Patterns in functional diversity of organisms at large spatial scales can provide insight into possible responses to future climate change, but it remains a challenge to link large-scale patterns at the organismal level to their underlying physiological mechanisms. The climate variability hypothe...

2022-01-20 | MTBLS3627 | MetaboLights
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