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TranscriptomicsGlobal changes in gene expression in dermal fibroblasts with in vivo and in vitro deletion of the RBP-Jk gene
It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent tri...
ORGANISM(S): Mus musculus 
2012-06-11 | E-GEOD-36359 | biostudies-arrayexpress
TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
UnknownStk40 deletion elevates c-JUN protein level and impairs mesoderm differentiation.
Not available
S-EPMC6597834 | biostudies-literature
UnknownPromotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members.
Not available
S-EPMC2887941 | biostudies-literature
UnknownOpposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis.
Not available
S-EPMC2668374 | biostudies-literature
UnknownEfficient and Specific Generation of MSTN-Edited Hu Sheep Using C-CRISPR.
Not available
S-EPMC10298037 | biostudies-literature
TranscriptomicsDual function of Jnk1 and Jnk2 in hepatocytes is essential to protect against toxic liver injury
BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of activation correlates with the degree of inju...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-59602 | biostudies-arrayexpress
UnknownJUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia.
Not available
S-EPMC10661119 | biostudies-literature
UnknownStress-induced nucleoid remodeling in Deinococcus radiodurans is associated with major changes in Heat Unstable (HU) protein dynamics.
Not available
S-EPMC11194088 | biostudies-literature
UnknownStructural insights into catalysis and dimerization enhanced exonuclease activity of RNase J.
Not available
S-EPMC4477667 | biostudies-literature
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