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TranscriptomicsAblation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair [maturation stage]
Cell fate is defined by specific transcriptional program. Here, we provide evidence that the transcriptional coactivator, Mediator 1 (MED1), is critical in determining the cell fate of ectodermal epithelia. MED1 ablation disrupted enamel formation and generated hair adjacent to the incisors. Deletio...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-50502 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 regulates bulge keratinocyte stem cells and accelerates epidermal regeneration after injury [10wk keratinocyte]
Transcriptional coactivator Mediator complex facilitates transcription of various transcription factors. Previously, we have generated Med1 conditional null mice, where a critical subunit of Mediator, Med1, is removed from keratinocytes. Here we present evidence that ablation of Med1 accelerated epi...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50672 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 regulates bulge keratinocyte stem cells and accelerates epidermal regeneration after injury [skin wound]
Transcriptional coactivator Mediator complex facilitates transcription of various transcription factors. Previously, we have generated Med1 conditional null mice, where a critical subunit of Mediator, Med1, is removed from keratinocytes. Here we present evidence that ablation of Med1 accelerated epi...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50670 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 regulates bulge keratinocyte stem cells and accelerates epidermal regeneration after injury [10wk skin]
Transcriptional coactivator Mediator complex facilitates transcription of various transcription factors. Previously, we have generated Med1 conditional null mice, where a critical subunit of Mediator, Med1, is removed from keratinocytes. Here we present evidence that ablation of Med1 accelerated epi...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50671 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 regulates bulge keratinocyte stem cells and accelerates epidermal regeneration after injury.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50673 | biostudies-arrayexpress
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