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GenomicsE2F7 represses a transcriptional network of oscillating cell cycle genes to control S-phase progression.
E2F transcription factors are known to be important for timely activation of G1/S and G2/M genes required for cell cycle progression, but transcriptional mechanisms for deactivation of cell cycle regulated genes are unknown. Here, we show that E2F7 is highly expressed during mid to late S-phase, occ...
ORGANISM(S): Homo sapiens 
2012-01-04 | E-GEOD-32673 | biostudies-arrayexpress
UnknownFeasibility Trial of Tailored Home Modifications: Process Outcomes.
Not available
S-EPMC5744715 | biostudies-literature
TranscriptomicsA Gene Expression Signature for Chemoradiosensitivity of Colorectal Cancer Cells
In this study, we use cancer cell lines to investigate the molecular differences between resistant and responsive colorectal cancer cells. Since the treatment of patients with locally advanced rectal cancers involves chemoradiotherapy (CT/RT), we specifically implemented an in vitro protocol that m...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-20298 | biostudies-arrayexpress
UnknownGenomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy.
Not available
S-EPMC6459729 | biostudies-literature
ProteomicsNudt21 controls cell fate by connecting alternative polyadenylation to chromatin signaling
Cell fate transitions involve rapid changes of gene expression patterns and global chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood. Here, we used transcription-factor induced reprogramming of somatic cells into pluripotent cells to screen for novel regulat...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-08 | PXD008078 | Pride
Nudt21 tmt 
UnknownFAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation.
Not available
S-EPMC7790828 | biostudies-literature
TranscriptomicsWB001A: Genome-wide analysis reveals NRP1 as a critical HIF1-E2F7 target gene in the regulation of motor neuron guidance in vivo
In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1α, as we show that expression of E2F7, like HIF1α, is induced in hypoxia, and because of the previously reported ability of E2F7 to interact with HIF1α. Our genome-wide analysis uncovers a transcrip...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-66750 | biostudies-arrayexpress
UnknownSmall-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Not available
S-EPMC8421361 | biostudies-literature
TranscriptomicsCP001: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35701 | biostudies-arrayexpress
TranscriptomicsCP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35703 | biostudies-arrayexpress
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