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TranscriptomicsThe nucleoid-associated protein HU controls three regulons that coordinate virulence and general physiology in Salmonella enterica serovar Typhimurium
The regulon of genes controlled by the HU nucleoid-associated proteins was examined in Salmonella enterica serovar Typhimurium (S. Typhimurium). DNA microarrays were used to detect the effect on the bacterial transcriptome of knockout mutations in the hupA, the hupB and in both the hupA and hupB gen...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-03-22 | E-GEOD-22860 | biostudies-arrayexpress
TranscriptomicsRsk2 controls synovial fibroblast hyperplasia and the course of arthritis.
To understand differences in the pathogenesis of synovial hyperplasia during TNF-induced arthritis, we compared the global gene expression of hTNFtg and hTNFtg;Rsk2-/y primary synovial fibroblasts. Murine fibroblast-like synoviocytes (FLS) were isolated from the hind paws of hTNFtg and hTNFtg;Rsk2-/...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-52992 | biostudies-arrayexpress
ProteomicsTemporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing
BK polyomavirus (BKPyV) is a small DNA virus that establishes a life-long persistent infection in the urinary tract of most people. BKPyV is known to cause severe morbidity in renal transplant recipients and can lead to graft rejection. The simple 5.2 kilobase pair dsDNA genome expresses just seven ...
ORGANISM(S): Homo sapiens (Human) BK polyomavirus MM 
2019-05-23 | PXD013940 | Pride
Quantitative proteomics  tandem mass tag  systems virology  polyomavirus  interferon  immune evasion  innate immunity  cell cycle 
ProteomicsA Quantitative Proteome Map of the Human Body
In this study, we quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-30 | MSV000086387 | MassIVE
UnknownSelective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity.
Not available
S-EPMC11148642 | biostudies-literature
TranscriptomicsE.coli MG1655M-NM-^T6/pCA24N-dinJ treated with erythromycin vs. MG1655M-NM-^T6/pCA24N
Antitoxins are becoming recognized as proteins that regulate more than their own synthesis; for example, we found previously that antitoxin MqsA represses the gene encoding the stationary phase sigma factor RpoS. Here, we investigated the physiological role of antitoxin DinJ of the DinJ/YafQ toxin/a...
ORGANISM(S): Escherichia coli 
2012-07-08 | E-GEOD-30692 | biostudies-arrayexpress
MetabolomicsA Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease
Identification of chronic kidney disease patients at risk of progressing to end-stage renal disease (ESRD) is essential for treatment decision-making and clinical trial design. Here, we explored whether proton nuclear magnetic resonance (NMR) spectroscopy of blood plasma improves the currently best ...
2019-07-26 | MTBLS798 | MetaboLights
UnknownFrequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice.
Not available
S-EPMC5681573 | biostudies-literature
UnknownPhotoisomerization of phytochrome's chromophore: a vibrational spectroscopic view on the primary ground state processes.
Not available
S-EPMC12703697 | biostudies-literature
TranscriptomicsTBCRC 001: Randomized Phase II Study of Cetuximab in Combination with Carboplatin in Stage IV Triple Negative Breast Cancer
Abstract Background. Epidermal growth factor receptor (EGFR) is a targetable molecule in basal-like breast cancer, which comprises most “triple negative” breast cancer (TNBC), the only breast cancer subtype without established targeted therapy. Methods. In this randomized phase II trial, metastatic ...
ORGANISM(S): Homo sapiens 
2012-07-13 | E-GEOD-23428 | biostudies-arrayexpress
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