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ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
2024-08-02 | PXD054574 |
ProteomicsQuantitiave analysis of protein methylome reveals the cellular response to ionizing radiation
Protein methylation plays important roles in DNA damage signaling. To date, there is still a lack of global profiling of whole-cell methylation changes during the DNA damage response and repair. In this study, using HILIC affinity enrichment combined with MS analysis, we conducted a quantitative ana...
ORGANISM(S): Homo Sapiens 
2022-02-14 | PXD031655 |
UnknownA Congenital hydrocephalus-causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation
Not available
S-SCDT-10_15252-EMBR_202255843 | biostudies-other
ProteomicsRAP-MS analysis of LncRNA BGL3 interacting proteins in cells
Long non-coding RNAs (lncRNAs) are emerging regulators of genomic stability and human disease. However, the molecular mechanisms by which nuclear lncRNAs directly contribute to DNA damage responses remain largely unknown. Using RNA antisense purification coupled with quantitative mass spectrometry (...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018186 | Pride
Lncrna bgl3 lc-ms 
ProteomicsProteomics Analysis of Human Obesity and Metabolic Syndrome Serum
Metabolic syndrome (MS) is a cluster of risk factors that can lead to a disorder of energy utilization and storage and raises risk for heart disease and other health problems. Obesity is a prevalent metabolic disorder in the developed countries and in large parts of developing world that is one of m...
ORGANISM(S): Homo Sapiens 
2022-07-21 | PXD035512 |
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