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ProteomicsIP-MALDI-MS assay LOD for VP40 by targeting two peptide variants
We developed a quantitative assay for carefully selected VP40 peptide variants. We selected two peptides, LGPGIPDHPLR from EBOV VP40 and LRPILLPGK from BDBV VP40 to generate pan-peptide variants antibodies. Potential structural difference in virion particles affect the efficiency of VP40 liberation ...
ORGANISM(S): Ebolavirus 
2021-11-02 | PXD026048 | Pride
Immunoprecipitation Vp40 
ProteomicsSecretome from TXNIP knockout human colorectal cell line (DLD1)
Chemotherapy, the standard of care treatment for cancer patients with advanced disease, has been increasingly recognised to activate host immune responses to produce durable outcomes. Here, in colorectal adenocarcinoma (CRC) we identify oxaliplatin-induced Thioredoxin Interacting Protein (TXNIP), a ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-12 | PXD051666 | Pride
Human Txnip Colorectal Secreted 
TranscriptomicsInfluence of Slug/SNAI2 on global gene expression in CRC cells and tumors
To establish the role of Slug in CRC, we created a genetic CRC model for Slug expression. As parental cells, we selected HT-29 cells that display a pronounced epithelial phe-notype. HT-29 cells were transfected with Slug, and two stable Slug-expressing clones. (Slug1, Slug2) were isolated. As transf...
ORGANISM(S): Mus musculus 
2022-06-11 | E-MTAB-11812 | biostudies-arrayexpress
UnknownSingle-cell transcriptomics identifies Gadd45b as a regulator of herpesvirus-reactivating neurons
Not available
S-SCDT-EMBOR-2021-53543-T | biostudies-other
TranscriptomicsTranscriptional profiling of 7SK knockdown in mouse embryonic stem cells
Transcriptome profiling of mouse embryonic stem cells following antisense knockdown of the non-coding RNA 7SK.
ORGANISM(S): Mus musculus 
2013-09-09 | E-MTAB-1585 | biostudies-arrayexpress
UnknownThe MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas
Not available
S-SCDT-10_1038-S44321-024-00105-2 | biostudies-other
TranscriptomicsDual IRE1 RNase functions dictate glioblastoma development
The transcriptome dataset has been used to validate on a GBM patient cohort (n=117) the IRE1-dependent gene expression signature identified in U87 cell line.
ORGANISM(S): Homo sapiens 
2018-01-09 | E-MTAB-6326 | biostudies-arrayexpress
ProteomicsArtificial intelligence defines protein-based classification of thyroid nodules
We applied PCT-DIA on a total of 1161 nodules from 1133 patients using either tissue cores (1 mm diameter; 0.5–1 mm depth) punched from regions of interest marked on retrospective FFPE tissue blocks or prospective cytology specimens from FNA aspirates. The samples comprise (i) a discovery set of FFP...
ORGANISM(S): Homo Sapiens 
2022-09-07 | PXD036554 |
UnknownA benchmark of expert-level academic questions to assess AI capabilities.
Not available
S-EPMC12851929 | biostudies-literature
UnknownDemographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry.
Not available
S-EPMC3329234 | biostudies-literature
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