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UnknownUnderstanding the polypharmacological anticancer effects of Xiao Chai Hu Tang via a computational pharmacological model.
Xiao Chai Hu Tang (XCHT), a traditional herbal formula, is widely administered as a cancer treatment. However, the underlying molecular mechanisms of its anticancer effects are not fully understood. In the present study, a computational pharmacological model that combined chemical space mapping, mol...
S-EPMC4043560 | biostudies-literature
UnknownThe Oncologist, 2025, Vol, XX, Issue XX Predictive role of ARID1A and B2M mutations and the antigen presentation pathway in the efficacy of definitive chemoradiotherapy for cervical cancer.

Background and purpose

Definitive chemoradiotherapy (dCRT) is the standard treatment for locally advanced cervical cancer (LACC), yet patients experience considerable variability in disease-free survival (DFS). This study aimed to identify molecular biomarkers associated with response to dCR...
S-EPMC12204396 | biostudies-literature
UnknownRenal cell carcinoma with succinate dehydrogenase A mutation: A case report and literature review.
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare subtype of RCC characterized by the presence of a germline mutation in one of the four subunits of the SDH enzyme complex (SDHA, SDHB, SDHC and SDHD). Together with a somatic second hit, these variants lead to the loss of f...
S-EPMC11632410 | biostudies-literature
TranscriptomicsExpression data from early rice endosperm
We used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of regulated genes during this process. Rice endosperm at 2 days after pollination(DAP) was selected for RNA extraction and hybridization on Affymetrix microarrays. We sou...
ORGANISM(S): Oryza sativa 
2015-09-01 | E-GEOD-57615 | biostudies-arrayexpress
GenomicsGenome-wide maps of DNA methylation state in rice embryo and endosperm
We report the application of methylacytosine immunoprecipetation combined with Illumina sequencing (MeDIP-seq) for high-throughput profiling of DNA methylation in rice embryo 3, 6, 9 DAP and endosperm 2, 3, 6, 9 DAP. A total number of 12-14 million of 2×49 bp paired-end reads was generated for each ...
ORGANISM(S): Oryza sativa 
2015-09-01 | E-GEOD-57706 | biostudies-arrayexpress
UnknownCongenital heart disease-associated pulmonary dysplasia and its underlying mechanisms.
Clinical observation indicates that exercise capacity, an important determinant of survival in patients with congenital heart disease (CHD), is most decreased in children with reduced pulmonary blood flow (RPF). However, the underlying mechanism remains unclear. Here, we obtained human RPF lung samp...
S-EPMC9925164 | biostudies-literature
UnknownLonger Time Interval from Neoadjuvant Chemoradiation to Surgery is Associated with Poor Survival for Patients Without Clinical Complete Response in Oesophageal Cancer.

Background

The optimal interval between neoadjuvant therapy and oesophagectomy for oesophageal cancer remains controversial.

Methods

Patients with locally advanced oesophageal squamous cell carcinoma (ESCC) who received neoadjuvant chemoradiotherapy followed by oesophagectomy between ...
S-EPMC9628481 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
UnknownCRISPR/Cas13 sgRNA-Mediated RNA-RNA Interaction Mapping in Live Cells with APOBEC RNA Editing.
Current research on long non-coding RNA (lncRNA) has predominantly focused on identifying their protein partners and genomic binding sites, leaving their RNA partners largely unknown. To address this gap, the study has developed a method called sarID (sgRNA scaffold assisted RNA-RNA interaction dete...
S-EPMC11615753 | biostudies-literature
UnknownDifferent reactive profiles of calmodulin in the CSF samples of Chinese patients of four types of genetic prion diseases.

Background and purpose

Calmodulin (CaM) levels exhibit significant elevation in the brain tissue of rodent and cell line models infected with prion, as well as in the cerebrospinal fluid (CSF) samples from patients diagnosed with sporadic Creutzfeldt-Jakob disease (sCJD). However, the status...
S-EPMC10881788 | biostudies-literature
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