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ProteomicsStudy on the inhibitory effect and mechanism of VOCs of a deep-sea bacteria on Pseudomonas aeruginosa
In order to elucidate the potential mechanism of resistance of active substances to PAO1, we performed a 4D Lable Free proteomic analysis to compare the differentially expressed proteins of PAO1 under the stress of active substances.
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2024-06-16 | PXD045249 | Pride
Pseudomonas aeruginosa pao1 proteome analysis 
ProteomicsPersulfidation alters gene regulatory programs and promotes endothelial specification
Endogenously generated sulfides are conserved among species and tissues and exert multiple effects through diverse mechanisms. Although sulfides have been linked to cell fates, their role in pluripotent stem cell commitment remains unknown. Here we discovered that during directed differentiation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD071015 | Pride
Sulfide supplementation Endothelial commitment Persulfidation Stem cells 
MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
UnknownDeciphering the chemical profile and pharmacological mechanism of Jinlingzi powder against bile reflux gastritis using ultra-high performance liquid chromatography coupled with Q exactive focus mass spectrometry, network pharmacology, and molecular docking.
Not available
S-EPMC10623248 | biostudies-literature
UnknownXPF expression and its relationship with the risk and prognosis of colorectal cancer.
Not available
S-EPMC7789628 | biostudies-literature
ProteomicsExosomal Proteomics Reveals Fatty Acid Metabolism Linked to Gefitinib Resistance in Non-Small Cell Lung Cancer
Extracellular vesicles (EVs) serve as critical mediators of intercellular communication, facilitating drug resistance in tumor microenvironments by transferring bioactive components like proteins. Despite their potential role in non-small cell lung cancer (NSCLC), systematic investigations into exos...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD068676 | Pride
Nsclc Proteomics Exosomes Gefitinib resistance Fatty acid metabolism 
ProteomicsA Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
Neuroendocrine prostate cancer (NEPC) persists in a profoundly hypoxic microenvironment, yet the mechanisms enabling tumor adaptation to this metabolically challenging niche remain undefined. Here, we identify the lipid kinase PIKfyve as overexpressed in NEPC, functioning as a central node in a stre...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076640 | Pride
Genomicsena-DATASET-BIOPIC-06-06-2018-15:24:14:117-163 - samples
bulk RNA-seq data of the 5 HCC patinets. Single cell RNA seq data of these patients was under the accession number EGAD00001003337
EGAD00001004148 | EGA
Genomicsena-DATASET-BIOPIC-06-06-2018-15:55:49:835-165 - samples
bulk Exome-seq data of the 5 HCC patinets. Single cell RNA seq data of these patients was under the accession number EGAD00001003337
EGAD00001004149 | EGA
Genomicsena-DATASET-BIOPIC-16-05-2017-14:34:15:534-498 - samples
T cells isolated from peripheral blood, tumors and adjacent normal tissues from six hepatocellular carcinoma patients. SmartSeq2 and Tang2009 protocol were used to amplify RNA from single T cells. High depth enables simultaneously expression profiling and TCR assembling.
EGAD00001003337 | EGA
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