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MetabolomicsTherapeutic effects of traditional Chinese medicine compound Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota

Hua-Feng-Dan is a traditional Chinese medicine compound used to treat ischemic stroke, but little is known about its therapeutic mechanism. This study explored whether and how the mechanism involves readjustment of gut microbiota. Rats were subjected to middle cerebral artery occlusion as a model...

2025-01-06 | MTBLS10818 | MetaboLights
TranscriptomicsAdenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRN...
ORGANISM(S): Homo sapiens 
2016-09-05 | E-GEOD-60217 | biostudies-arrayexpress
TranscriptomicsThe genome of Streptomyces rimosus shows a novel structure compared to other Streptomyces
This study compared the genome of Streptomyces rimosus rimosus against that of Streptomyces coelicolor. It also compared 4 strains with changes in oxytetracycline production and derived from G7, the type strain, against G7. Duplicate samples, each replicate may be found in the corresponding suppleme...
ORGANISM(S): Streptomyces rimosus 
2010-05-26 | E-GEOD-10126 | biostudies-arrayexpress
UnknownPhosphorus-Sulfur Heterocycles Incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O Scaffold: One-Pot Synthesis and Crystal Structure Study.
Not available
S-EPMC6151443 | biostudies-literature
TranscriptomicsSaccharomyces cerevisiae BY4741 cells treated with n-alkanes
Transcripitonal profiling of Saccharomyces cerevisiae treated with 2% n-alkanes vs untreatment Multiple condition experiment, S. cerevisiae treated with n-alkanes (n-nonane, n-decane, n-undecane, n-dodecane, respectively) for 24hrs or 48hrs, compared to control (those without treatment)
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-07 | E-GEOD-38653 | biostudies-arrayexpress
UnknownEffect of H₂S on the circadian rhythm of mouse hepatocytes.
Not available
S-EPMC3292508 | biostudies-literature
GenomicsGenome-wide profiling of DNA methylation in two Arabidopsis ecotypes and their reciprocal hybrids - Bisulfite-seq
Heterosis is a fundamental biological phenomenon characterized by the superior performance of a hybrid over its parents in many traits, but the underlying molecular basis remains elusive. To investigate whether DNA methylation plays a role in heterosis, we compared at single base-pair resolution th...
ORGANISM(S): Arabidopsis thaliana 
2011-12-22 | E-GEOD-34657 | biostudies-arrayexpress
GenomicsDegradation of unmethylated miRNA/miRNA*s by a DEDDy-type 3’ to 5’ exoribonuclease ATRIMMER2 in Arabidopsis
3’ end methylation catalyzed by HUA ENHANCER1 (HEN1) is a crucial step of small RNA stabilization in plants, yet how unmethylated small RNAs undergo degradation remains largely unknown. Using a reverse genetic approach, we here show that ATRIMMER2 (ATRM2), a DEDDy-type 3’ to 5’ exoribonuclease, acts...
ORGANISM(S): Arabidopsis thaliana 
2018-12-01 | GSE107070 | GEO
ProteomicsSelective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by activating a shunt pathway that generates the toxic metabolite 24(S),25-epoxycholesterol
LUM2_708738 - MM0299-probe bound protein; LUM2_708739 - MM0299 competition; LUM2_850369 - Ro-alkyne bound protein; LUM2_850370 - Ro 48-8071 competition
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-11 | MSV000091046 | MassIVE
TranscriptomicsAcid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation
Global transcriptional analysis of acid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation pH is a major environmental factor that regulates gene expression in many bacteria. Streptococcus mutans in dental biofilms is regularly exposed to cycles of a...
ORGANISM(S): Streptococcus mutans 
2010-05-22 | E-GEOD-15125 | biostudies-arrayexpress
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