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TranscriptomicsTranscription profiling of human Jurkat T leukemia cells to detect anticancer metabolites discovered by computational metabolomics
CoMet, a fully automated Computational Metabolomics method to predict changes in metabolite levels in cancer cells compared to normal references has been developed and applied to Jurkat T leukemia cells with the goal of testing the following hypothesis: up or down regulation in cancer cells of the e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9648 | biostudies-arrayexpress
MetabolomicsTargeted plasma metabolomics combined with machine learning for the diagnosis of acute SARS-CoV-2

The routine clinical diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely restricted to real-time reverse transcription polymerase chain reaction (RT-qPCR), and tests that detect SARS-CoV-2 nucleocapsid antigen. Given the diagnostic delay and suboptimal sensitivity...

2024-08-26 | MTBLS6739 | MetaboLights
UnknownStructure of the full-length Clostridium difficile toxin B.
Not available
S-EPMC6684407 | biostudies-literature
ProteomicsMatrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Cartilage aging is a quintessential feature of knee osteoarthritis, and extracellular matrix (ECM) stiffening is a typical feature of cartilage aging. However, the mechanism of ECM stiffening to influence chondrocytes and downstream molecules is still poorly understood. Here, we mimicked the physiol...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-16 | PXD046993 | Pride
Cartilago articularis，matrix stiffness，osteoarthritis 
UnknownIdentification of metabolites with anticancer properties by computational metabolomics.
Not available
S-EPMC2453147 | biostudies-literature
UnknownStructure and conformational dynamics of <i>Clostridioides difficile</i> toxin A.
Not available
S-EPMC8924006 | biostudies-literature
UnknownIn silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer.
Not available
S-EPMC8044145 | biostudies-literature
UnknownResults of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia.
Not available
S-EPMC4809642 | biostudies-literature
ProteomicsDisrupting metformin adaptation of hepatocellular carcinoma by targeting TOMM34/ATP5B axis
As a well-known anti-diabetic drug, metformin has been repurposed for cancer treatment, but drug resistance and tumor metastasis observed recently have challenged its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characteriz...
ORGANISM(S): Homo Sapiens 
2022-07-14 | PXD035365 |
UnknownOptimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo.
Not available
S-EPMC9728973 | biostudies-literature
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