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ProteomicsShort-term mild temperature-stress-induced alterations in C. elegans phosphoproteome
Exposure to mild early-life stresses can slow down the aging process, in which protein phosphorylation might be an essential regulator. Currently, the understanding of phosphorylation-based regulatory networks under mild early-life stress remains elusive. Herein, we systematically analyzed the phosp...
ORGANISM(S): Caenorhabditis elegans 
2020-09-17 | PXD021081 | Pride
Phosphoproteomics  c. elegans  mild temperature  lifespan  mild stresses 
UnknownProtective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke.
Not available
S-EPMC2984508 | biostudies-literature
ProteomicsCross-species complementation reveals conserved functions for EARLY FLOWERING 3 between monocots and dicots.
Plant responses to the environment are shaped by the external stimuli and internal signaling pathways. In both the model plant Arabidopsis thaliana and crop species, circadian clock factors have been identified as critical for growth, flowering and circadian rhythms. Outside of A. thaliana, however,...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-01-08 | PXD006352 | Pride
Arabidopsis Ap-ms Circadian signaling Orbitrap 
ProteomicsEnabling Photoactivated Cross-linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-cleavable Cross-linkers
Cross-linking mass spectrometry (XL-MS) is a powerful tool for studying protein-protein interactions and elucidating architectures of protein complexes. While residue-specific XL-MS studies have been very successful, accessibility of interaction regions non-targetable by specific chemistries remain ...
ORGANISM(S): Bos taurus (Bovine) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-07 | PXD022690 | Pride
26s proteasome Photocross-linking Sdaso Bsa 
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
ProteomicsOne-day thermal regime extends lifespan
Environmental factors such as temperature can modulate animal’s lifespan. However, the underlying mechanisms remain largely undefined. Through proteomic analysis of C. elegans at different time points (young adult, middle age, and old age) and under two temperature conditions (20°C and 25°C), we fou...
ORGANISM(S): Caenorhabditis elegans 
2023-03-11 | PXD024916 | Pride
C. elegans Proteomics Lifespan Temperature 
TranscriptomicsWhite Cells Facilitate Opposite- and Same-Sex Mating of Opaque Cells in Candida albicans
Modes of sexual reproduction in eukaryotic organisms are highly diversified. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally and morphologically differentiated ...
ORGANISM(S): Candida albicans 
2014-10-23 | E-GEOD-56039 | biostudies-arrayexpress
MetabolomicsDiallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice
Diallyl disulfide (DADS), a garlic extract also known as allicin, has been reported to have numerous biological activities, including anticancer, antifungal, and inflammation-inhibiting activities, among others. Although many studies have assessed whether DADS can treat Candida albicans infec...
2022-05-03 | MTBLS3750 | MetaboLights
UnknownPien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells.
Not available
S-EPMC6220046 | biostudies-literature
TranscriptomicsReciprocal regulation of genes expression by Ephedra herba in mouse brain
A microarray analysis was conducted using the brain tissue of mouse orally administrated aqueous extracts of Ephedra herba, in which the expression level of many genes were altered depending on the duration of treatment time. In particular, temporal changes in the expressions of genes can be classif...
ORGANISM(S): Mus musculus 
2009-04-04 | E-GEOD-15536 | biostudies-arrayexpress
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