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MetabolomicsUntargeted metabolomics of long-term drug intervention under standard diet in mice associated with lifespan

This study investigates urinary metabolic differences in young mice, aged mice, and aged mice supplemented with long-term drug intervention under standard diet. Untargeted metabolomics was performed using UHPLC-MS/MS in both positive (POS) and negative (NEG) ionization modes. The dataset provides...

2026-05-07 | MTBLS12889 | MetaboLights
TranscriptomicsGene Expression Defines Natural Changes in Mammalian Lifespan
Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineage...
ORGANISM(S): Bos taurus 
2015-02-17 | E-GEOD-43013 | biostudies-arrayexpress
TranscriptomicsSIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.
The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespa...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-46895 | biostudies-arrayexpress
TranscriptomicsMembers of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family1, 2, but less is known about the role of other histone modifications in l...
ORGANISM(S): Caenorhabditis elegans 
2011-07-08 | E-GEOD-30505 | biostudies-arrayexpress
MetabolomicsMitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan
Not available
ORGANISM(S): Rattus norvegicus 
ST001526 | MetabolomicsWorkbench
TranscriptomicsThe SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+ deacetylase, improves metabolism and confers protection against physiological and cognitive distur...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-50987 | biostudies-arrayexpress
TranscriptomicsSuppression of Transcriptional Drift Extends C. elegans Lifespan by Postponing the Onset of Mortality
Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that precede mortality is unclear. Here, we uncover...
ORGANISM(S): Caenorhabditis elegans 
2016-01-06 | E-GEOD-63528 | biostudies-arrayexpress
MetabolomicsA cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Heart) part-IV
Not available
ORGANISM(S): Mus musculus 
ST001702 | MetabolomicsWorkbench
MetabolomicsA cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Liver) part-III
Not available
ORGANISM(S): Mus musculus 
ST001701 | MetabolomicsWorkbench
MetabolomicsA cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Serum) part-II
Not available
ORGANISM(S): Mus musculus 
ST001700 | MetabolomicsWorkbench
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