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TranscriptomicsThe BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers
Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. RNAseq was performed in endogeno...
ORGANISM(S): Homo sapiens 
2014-09-14 | E-GEOD-58365 | biostudies-arrayexpress
GenomicsBACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.
The B cell-specific BACH2 transcription factor is required for affinity maturation of mature B cells. Here, we show that Bach2 mediates negative selection at the pre-B cell receptor checkpoint and functions as a critical safeguard against leukemogenesis. Bach2-mediated activation of p53 is required ...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-44420 | biostudies-arrayexpress
GenomicsCooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation
The transcriptional repressors BCL6 and BACH2 are crucial regulators of germinal center (GC) B-cell fate, and are known to interact and repress transcription of PRDM1, a key driver of plasma cell differentiation. How these factors cooperate is not fully understood. Herein we show that while GC forma...
ORGANISM(S): Homo sapiens 
2013-11-17 | E-GEOD-47784 | biostudies-arrayexpress
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