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TranscriptomicsSost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emergning as key regulatory proteins with great promise as therapeutic agents for bone disorders. Until recently Sost and its paralog Sostdc1 have been described as growth factors ...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-44325 | biostudies-arrayexpress
ProteomicsLong-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer
Deregulated gene expression is a hallmark of cancer, however most studies to date have analyzed short-read RNA-sequencing data with inherent limitations. Here, we combine PacBio long-read isoform sequencing (Iso-Seq) and Illumina paired-end short read RNA sequencing to comprehensively survey the tra...
ORGANISM(S): Homo sapiens (Human) 
2021-02-02 | PXD023373 | Pride
Isoform sequencing (iso-seq) Alternative promoters Gastric cancer Long-read sequencing 
UnknownActivation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP.
Not available
S-EPMC3871513 | biostudies-literature
TranscriptomicsAscl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state
Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development fo...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-27174 | biostudies-arrayexpress
ProteomicsDeletion of miR-15a/16-1 in murine germinal center B-cells.
Given the tumor suppressing function of miR-15a/16-1 cluster, we studied its role in the germinal center B-cells that give rise to most lymphoid malignancies.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021323 | Pride
B-cell Proteomics Mouse Germinal center 
TranscriptomicsTranscription profiling by array of honey bee workers orally exposed to two different pesticides (coumaphos, fluvalinate)
We explored the impact of coumaphos and fluvalinate, the two most abundant and frequently detected pesticides in the hive, on genome-wide gene expression patterns of honey bee workers. We found significant changes in 1118 transcripts, including genes involved in detoxification, behavioral maturation...
ORGANISM(S): Apis mellifera 
2014-11-14 | E-MTAB-3025 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skin from p63 null and wild type mice to identify genes that are directly or indirectly regulated by p63.
In the absence of p63 expression, the epidermis fails to commit to stratification, resulting in aborted skin development. In this study, gene expression profiles of E18.5 p63 null and wt skin, were compared in an effort to identify genes that are directly or indirectly regulated by p63. Experiment ...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3108 | biostudies-arrayexpress
UnknownCODA: quantitative 3D reconstruction of large tissues at cellular resolution.
Not available
S-EPMC10500590 | biostudies-literature
UnknownIntegrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of SmWRKY61 on Tanshinone Biosynthesis in Salvia miltiorrhiza and Salvia castanea.
Not available
S-EPMC8928407 | biostudies-literature
UnknownBlood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH.
Not available
S-EPMC5593822 | biostudies-literature
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