Sort   by:  
 Page size 
ProteomicsNoncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resistanc...
ORGANISM(S): Escherichia coli 
2026-01-12 | PXD069482 | Pride
Bispecific antibody Maldi-tof Noncanonical amino acid 
ProteomicsIntegrating Protein Language Models and Automatic Biofoundry for Enhanced Protein Evolution
Traditional protein engineering methods, such as directed evolution, while effective, are often slow and labor-intensive. Advances in machine learning and automated biofoundry present new opportunities for optimizing these processes. This study devises a protein language model-enabled automatic evol...
ORGANISM(S): Escherichia coli 
2024-12-25 | PXD058768 | Pride
Protein language models Protein engineering Directed evolution Automatic biofoundry 
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
ProteomicsLactylation of NAT10 promotes N4‐acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation
N4-acetylcytidine (ac4C), a conserved but recently rediscovered RNA modification on tRNAs, rRNAs and mRNAs, is catalyzed by N-acetyltransferase 10 (NAT10). Lysine acylation is a ubiquitous protein modification that controls protein functions. Our latest study demonstrates a NAT10-dependent ac4C modi...
ORGANISM(S): Homo Sapiens 
PXD049447 |
ProteomicsEnhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics
We present a high-sensitivity SCP workflow named Chip-Tip, identifying >5000 proteins in individual HeLa cells
ORGANISM(S): Homo Sapiens 
PXD054944 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
Sort   by:  
 Page size