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TranscriptomicsGenome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
SR proteins are well-characterized RNA binding proteins that promote exon inclusion by binding to exonic splicing enhancers (ESEs). However, it has been unclear whether regulatory rules deduced on model genes apply generally to activities of SR proteins in the cell. Here, we report global analyses o...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-44591 | biostudies-arrayexpress
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsIdentification of the methyl-CpG binding protein 2 (MeCP2) interacting proteins in the high molecular weight (HMW) extract prepared from the human HEK293T cells by immunoprecipitation coupled with mass spectrometry analysis
Identification of MeCP2 interacting proteins in HMW extract of HEK293T cells
ORGANISM(S): Homo Sapiens 
2021-08-30 | PXD021650 |
ProteomicsHuman colon cancer HCT116 cell LC/MSMS
Mitosis deregulation is a key event during carcinogenesis. Alternative splicing spectrum alteration plays a critical role during mitosis shift. However, the molecules responsible for dysregulated alternative splicing driving carcinogenetic mitosis remain poorly defined. Here, we demonstrate that can...
ORGANISM(S): Homo Sapiens 
2020-03-30 | PXD018242 |
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