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ProteomicsDistinct functions of RIPK1 ubiquitination in regulating its activation mediated by TNFR1 and TLRs signaling
We identified and quantified ubiquitination sites of WT RIPK1 and K627R mutant in TNF signaling pathway and 293T overexpression system
ORGANISM(S): Homo Sapiens Mus Musculus 
2020-10-23 | PXD022157 |
ProteomicsQuantitative proteomics reveals the crucial roles of Cathepsin D in bacterial infections
Bacterial resistance has become more and more widespread which seriously threatens human life and health. Therefore, using the natural immune system of host to kill bacteria is particularly fascinating. Here, using mass spectrometry analyses, we depicted the dynamic expression landscape of mitochond...
ORGANISM(S): Mus Musculus 
2020-05-13 | PXD016938 |
ProteomicsYi-xin-shu Capsule Ameliorates Cardiac Hypertrophy by Regulating RB/HDAC1/GATA4 Signaling Pathway in Abdominal Aorta Coarctation-Induced Rat Model
Background: Cardiac hypertrophy (CH) is the main pathological basis of malignant cadiovascular diseases such as chronic heart failure (CHF). Mitigating and preventing CH is the key strategy for the treatment of ventricular remodeling in CHF. Yi-Xin-Shu capsule (YXS) is highly applied in clinical tre...
ORGANISM(S): Rattus Rattus 
2021-05-26 | PXD026267 |
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
ProteomicsProteomics reveals the potential mechanism of Mrps35 controlling Listeria intracellular proliferation in macrophages
We performed the comprehensive proteomics to analyze the dynamic expression landscape of wild type and Mrps35 Knockdown Raw264.7 cells by Listeria infection over 6h. Based on the results of mass spectrometry, we presented a wide variety of hypotheses about the mechanism of Mrps35 controlling the Lis...
ORGANISM(S): Mus Musculus 
2020-10-22 | PXD022127 |
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