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A gene expression profiling sub-study was conducted in which colonic biopsy samples were collected for RNA extraction and hybridization to microarrays from 48 patients with UC who were participating in ACT 1, a placebo-controlled study of infliximab. Gene expression profiles from infliximab responde...
ORGANISM(S): Homo sapiens 
Niemann-Pick Type C disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet, lit...
ORGANISM(S): Mus musculus 
Patients with ulcerative colitis (UC) are at increased risk for colorectal cancer although mechanisms remain poorly understood. We sought to evaluate the role of miRNAs in neoplasia development in this high-risk population RNA was extracted from formalin fixed paraffin embedded tissue from  controls...
ORGANISM(S): Homo sapiens 
Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer and is associated with a poor prognosis. We have developed a new model of IBC derivated from the pleural effusion of a 49-year-old woman with metastatic secondary IBC. FC-IBC02 tumor cells were isolated from the p...
ORGANISM(S): Homo sapiens 
Significant interest has been devoted to the isolation of human pluripotent stem cells displaying the naive state of mouse embryonic stem cells. However, to what extent naive human cells isolated in culture resemble pluripotent cells in vivo remains unclear. Here we present three lines of evidence i...
ORGANISM(S): Homo sapiens 
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