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GenomicsActivation of the P-TEFb Complex by Lethal Prostate Cancer-Associated Enhancer RNAs [ChIP-Seq]
Castration resistant prostate cancer (CRPC) is a lethal disease1-4. Aberrant activation of the androgen receptor (AR) becomes a central mechanism contributing to the resistance of endocrine therapies2,3. Here we demonstrate that non-coding RNAs transcribed from the AR bound-enhancers RNAs (AR-eRNA...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-55031 | biostudies-arrayexpress
TranscriptomicsActivation of the P-TEFb Complex by Lethal Prostate Cancer-Associated Enhancer RNAs [RNA-Seq]
Castration resistant prostate cancer (CRPC) is a lethal disease1-4. Aberrant activation of the androgen receptor (AR) becomes a central mechanism contributing to the resistance of endocrine therapies2,3. Here we demonstrate that non-coding RNAs transcribed from the AR bound-enhancers RNAs (AR-eRNA...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-55030 | biostudies-arrayexpress
GenomicsActivation of P-TEFb by enhancer RNAs associated with lethal prostate cancer [ChIP-seq]
Castration resistant prostate cancer (CRPC) is a lethal disease. Sustained aberrant activation of androgen receptor (AR) becomes a central mechanism that contributes to endocrine therapy resistance. Here, we demonstrate that AR-bound enhancer RNAs (AR-eRNAs), including eRNA of the KLK3 (or PSA) ge...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-65066 | biostudies-arrayexpress
TranscriptomicsMeasure transcript integrity using RNA-seq data
Achieved biospecimens annotated with patient clinical characteristics are unique resources for translational research. However, RNA extracted from the achieved tissues is often degraded. RNA degradation can have a significant impact on the measure of transcript abundance that can lead to an increase...
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-70285 | biostudies-arrayexpress
GenomicsActivation of P-TEFb by androgen receptor-regulated enhancer RNAs in androgen deprivation conditions [ChIP-Seq]
Androgen receptor (AR) is required for castration resistant prostate cancer (CRPC) progression, but the function and disease relevance of AR-bound enhancers remain poorly understood. Here, we identify a group of AR-regulated enhancer RNAs (e.g. PSA eRNA) that are upregulated in CRPC cells, patient-...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-71704 | biostudies-arrayexpress
GenomicsThe cistrome and transcriptome landscape of androgen receptor splice variants in castration-resistant prostate cancer cells
The spliced variant forms of androgen receptor (AR-Vs) have been identified recently in castration-resistant prostate cancer (CRPC) cell lines and clinical samples. Here we identified the cistrome and transcriptome landscape of AR-Vs in CRPC cell lines and determine the clinical significance of AR v...
ORGANISM(S): Homo sapiens 
2014-09-10 | E-GEOD-58478 | biostudies-arrayexpress
GenomicsMapping ONECUT1 TF binding with ChIP-exo
The aim of this project is to locate the precise binding of the ONECUT1 transcription factor. NOTE: This study was updated on 7th May 2014. All samples, experiments, runs and files were replaced. This was due to an incorrect reagent being used in the earlier version.
ORGANISM(S): Mus musculus 
2014-05-10 | E-MTAB-2060 | biostudies-arrayexpress
ProteomicsSPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
Geminin ubiquitin modification site mapping, Geminin coIP-mass spec
ORGANISM(S): Homo Sapiens 
2021-08-12 | PXD027915 |
ProteomicsSPOP mass spec in different treatment
293T cells were transfected with S, Flag, and Biotin-binding-protein-(streptavidin)-binding-peptide (SFB) triple-tagged backbone vector or SFB-tagged SPOP. Twenty-four h after transfection, control cells were treated with DMSO (Group 1) and SFB-SPOP transfected cells were treated with DMSO (Group 2)...
ORGANISM(S): Homo Sapiens 
2021-09-06 | PXD028210 |
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