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TranscriptomicsLncPHx2 RNA-interactome
LncPHx2 RNA-interactome study realed that LncPHx2 is associated with multiple RNAs Biotinylated DNA probes targeting LncPHx2 were used to precipitate endogenous LncPHx2 and associated RNAs from Hepa 1-6 cells. The associated RNAs were sequenced and 415 unique transcripts were identified.
ORGANISM(S): Mus musculus 
2015-06-27 | E-GEOD-70342 | biostudies-arrayexpress
TranscriptomicsPartial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration
Gene expression analysis showed that LncPHx2 depletion resulted in upregulation of mRNAs encoding proteins known to promote cell proliferation, including MCM components, DNA polymerases, histone proteins, and transcription factors RNA-seq analysis was performed on livers of mice subjected to PHx or ...
ORGANISM(S): Mus musculus 
2015-06-26 | E-GEOD-70283 | biostudies-arrayexpress
TranscriptomicsGenome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [RNA-seq]
Nonsense-mediated mRNA decay (NMD) surveillance pathways are best known to be involved in the degradation of mRNA with premature termination codons (PTCs). More recent studies demonstrate that the role of NMD pathways goes well beyond the degradation of PTC containing mRNA, into the regulation of ce...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27199 | biostudies-arrayexpress
ProteomicsDIA-PASEF–based total proteome profiling of HeLa cells expressing nuclear or cytosolic p62 condensates
Cells were lysed in 6 M guanidine-HCl, 100 mM HEPES-NaOH, pH7.5, 10 mM TCEP, and 40 mM CAA. The lysates were dissolved by heating and sonication, followed by centrifugation at 20,000 × g for 15 min at 4 °C. The supernatants were recovered, and proteins (20 µg each) were purified by the SP3 method an...
ORGANISM(S): Homo Sapiens (human) 
2025-12-30 | PXD072518 | JPOST Repository
ProteomicsDIA-PASEF–based FLAG-IP proteomic analysis of nuclear or cytosolic p62 condensates in HeLa cells
Cells were cross-linked with 0.1% formaldehyde for 10 min at 25 °C and quenched with 100 mM glycine. After washing with HBS (20 mM HEPES-NaOH, pH 7.5, 150 mM NaCl), cells were lysed in HEPES-RIPA buffer (20 mM HEPES-NaOH, pH 7.5, 150 mM NaCl, 1 mM MgCl₂, 1 mM EGTA, 1% NP-40, 0.25% sodium deoxycholat...
ORGANISM(S): Homo Sapiens (human) 
2025-12-30 | PXD072519 | JPOST Repository
TranscriptomicsDosage imbalance of NMD genes is associated with intellectual disability
Nonsense-mediated mRNA decay (NMD) functions to degrade transcripts bearing premature stop codon (PTC) and is a crucial regulator of gene expression. NMD and the UPF3B gene have been implicated as the cause of various forms of intellectual disability (ID) and other neurological symptoms. Here, we re...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35420 | biostudies-arrayexpress
UnknownEpithelial-Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress.
Not available
S-EPMC9322750 | biostudies-literature
UnknownA novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation.
Not available
S-EPMC10938783 | biostudies-literature
TranscriptomicsGenome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [CNV]
Nonsense-mediated mRNA decay (NMD) surveillance pathways are best known to be involved in the degradation of mRNA with premature termination codons (PTCs). More recent studies demonstrate that the role of NMD pathways goes well beyond the degradation of PTC containing mRNA, into the regulation of ce...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27412 | biostudies-arrayexpress
TranscriptomicsGenome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [mRNA profiling]
Nonsense-mediated mRNA decay (NMD) surveillance pathways are best known to be involved in the degradation of mRNA with premature termination codons (PTCs). More recent studies demonstrate that the role of NMD pathways goes well beyond the degradation of PTC containing mRNA, into the regulation of ce...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27125 | biostudies-arrayexpress
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