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ProteomicsNovel insights into redox-based mechanisms for auranofin- induced rapid cancer cell death
One of the significant features of cancer cells is a persistent pro-oxidative status. Therefore, compared to their normal counterparts, the malignant cells are generally more dependent on antioxidants for cell survival and more vulnerable to further oxidative insults via pharmacolog-ical interventio...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036558 | Pride
Auranofin  oxidative stress  redox regulation  redoxome  cancer 
ProteomicsVitamin C-induced breast cancer cell death is associated with remodeling the redox state of cysteine-containing proteins involved in translation and cell cycle progression
Recent studies show vitamin C (VitC) pro-oxidant properties at high pharmacological concentrations which favor repurposing VitC as an anti-cancer therapeutic agent. However, redox-based anticancer properties of different forms of VitC are yet partially understood. We examined the difference between ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-16 | PXD013833 | Pride
Breast cancer Ascorbic acid Vitamin c Dehydroascorbic acid Oxidative stress Redoxome 
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