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UnknownAccurate prediction of protein function using statistics-informed graph networks.
Understanding protein function is pivotal in comprehending the intricate mechanisms that underlie many crucial biological activities, with far-reaching implications in the fields of medicine, biotechnology, and drug development. However, more than 200 million proteins remain uncharacterized, and com...
S-EPMC11297950 | biostudies-literature
Unknownβ-Carbon functionalization of amines via α-amino Cu-carbenes.
Limited by the weaker d-p π-backdonation capacity exhibited by copper catalysis in metal carbene chemistry and the available carbene precursors, the construction of α-amino copper carbenes had remained unrealized. Here, we report a leaving group-driven carbene precursor design based on an intermolec...
S-EPMC12787579 | biostudies-literature
UnknownAerosolized Zika virus infection in Guinea pigs.
Zika virus (ZIKV) is primarily transmitted through mosquito bites and sexual contact, and vertical transmission of ZIKV has also been observed in humans. In addition, ZIKV infection via unknown transmission routes has been frequently reported in clinical settings. However, whether ZIKV can be transm...
S-EPMC9553109 | biostudies-literature
UnknownRapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53-Dependent Apoptosis.
Cardiomyocytes differentiated from human pluripotent stem cells can serve as an unexhausted source for a cellular cardiac disease model. Although small molecule-mediated cardiomyocyte differentiation methods have been established, the differentiation efficiency is relatively unsatisfactory in multip...
S-EPMC5721819 | biostudies-literature
UnknownRNA-Sequencing, Connectivity Mapping, and Molecular Docking to Investigate Ligand-Protein Binding for Potential Drug Candidates for the Treatment of Wilms Tumor.
BACKGROUND Wilms tumor, or nephroblastoma, is a malignant pediatric embryonal renal tumor that has a poor prognosis. This study aimed to use bioinformatics data, RNA-sequencing, connectivity mapping, molecular docking, and ligand-protein binding to identify potential targets for drug therapy in Wilm...
S-EPMC7119447 | biostudies-literature
UnknownA Genomic-clinicopathologic Nomogram for the Preoperative Prediction of Lymph Node Metastasis in Bladder Cancer.
Preoperative lymph node (LN) status is important for the treatment of bladder cancer (BCa). Here, we report a genomic-clinicopathologic nomogram for preoperatively predicting LN metastasis in BCa. In the discovery stage, 325 BCa patients from TCGA were involved and LN-status-related mRNAs were selec...
S-EPMC6014062 | biostudies-literature
UnknownInvolvement of hydrogen sulfide in the progression of renal fibrosis.

Objective

Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered end...
S-EPMC6940064 | biostudies-literature
UnknownMagnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model.
Magnesium (Mg)-based biometal attracts clinical applications due to its biodegradability and beneficial biological effects on tissue regeneration, especially in orthopaedics, yet the underlying anabolic mechanisms in relevant clinical disorders are lacking. The present study investigated the effect ...
S-EPMC7185815 | biostudies-literature
UnknownThe Expression and Potential Role of Tubulin Alpha 1b in Wilms' Tumor.
We explored the difference in expression of tubulin alpha 1b (TUBA1B) between Wilms' tumor (WT) and normal tissues (NT) from in-house patients and databases, to determine TUBA1B expression in WT and the predictive pathways of coexpressed genes. In-house RNA-sequencing data were performed with WT and...
S-EPMC7468616 | biostudies-literature
UnknownSymptoms can predict COVID-19 pneumonia in patients infected with SARS-CoV-2 Omicron variants.
Pneumonia is a key criterion for the severity of COVID-19. Whether COVID-19 symptoms are indicators of pneumonia in patients infected with SARS-CoV-2 Omicron variants is unclear. 6200 non-hospitalized patients with COVID-19 from three sites in three hospitals were divided into three cohorts: Cohort ...
S-EPMC11615324 | biostudies-literature
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