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MetabolomicsMicrobiota-derived metabolites act as ecological effectors of colonization resistance against Salmonella Enteritidis

Colonization resistance is a fundamental ecological function of the gut microbiota that limits the expansion of enteric pathogens. Yet, the microbial effectors linking ecosystem homeostasis to pathogen control remain poorly understood. Here, we demonstrate that Salmonella Enteritidis (S. Enteriti...

2026-08-31 | MTBLS15505 | MetaboLights
ProteomicsDNAJB9 promotes epithelial-mesenchymal transition in the nasal epithelium of chronic rhinosinusitis by enhancing TRIM22-mediated IκBα degradation
This study investigates the functional role of DNAJB9 in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Using quantitative proteomics alongside human tissue analysis and murine models, we found that DNAJB9 is significantly upregulated in CRSwNP nasal epithelium and closely mi...
ORGANISM(S): Homo sapiens (Human) 
2026-06-17 | PXD079333 | Pride
Chronic sinusitis  epithelial-mesenchymal transition  dnajb9  ubiquitination  nf-κb 
ProteomicsBbubalis - Sperm, SC (Fuetal,theriogenology.2019)
abundance based on Spectral counting, Interaction consistency score: 9.5, Coverage: 12
ORGANISM(S): 89462 
2019-00-00 | 562539239 | PAXDB
GenomicsGlobal Mapping of H3K4me1 and H3K4me3 in human CD4+CD25+FOXP3+ Treg cells
Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differentiate between Treg and conventional T cells (Tconv) remain to be fully elucidated, especially at t...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26427 | biostudies-arrayexpress
TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-68091 | biostudies-arrayexpress
ProteomicsQuantitative Proteomic Analysis of buffalo ovaries
The ovary is the most important sexual organ of female mammals, and its corpus luteum plays a significant role in mammalian reproduction during the estrus cycle. Here we conducted a quantitative proteomic analysis using tandem mass tag (TMT)-labeling coupled with Nano-LC-MS/MS to explore the mechani...
ORGANISM(S): Bubalus Bubalis 
2019-10-30 | PXD016072 |
TranscriptomicsTranscriptome sequencing of naked mole rat, Heterocephalus glaber
Deep sequencing of mRNA from naked mole rat Analysis of ploy(A)+ RNA of different specimens: brain, kidney, liver from new born , 4 years old , 20 years old and 4 years old hypoxia-exposed naked mole rat
ORGANISM(S): Heterocephalus glaber 
2011-10-12 | E-GEOD-30337 | biostudies-arrayexpress
ProteomicsMolecular Phenomics of the Gut Ecosystem in COVID-19 Patients
Stool metaproteomics of COVID-19 patients and healthy subjects to discover host and microbial protein alterations of gut ecosystem.
ORGANISM(S): Homo Sapiens 
2020-12-14 | PXD023099 |
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