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ProteomicsEndothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3
Understanding the molecular mechanisms of pathological vascular remodeling is important for treating cardiovascular diseases and complications. Recent studies have highlighted a role of deubiquitinases in vascular pathophysiology. In this study, we investigated the role of a deubiquitinase, OTUD1, i...
ORGANISM(S): Homo sapiens (Human) 
2022-12-24 | PXD037926 | Pride
Huvec  lc-ms/ms 
ProteomicsMacrophage WEE1 promotes atherosclerosis via directly phosphorylating NF-κB p65 subunit and inducing inflammatory response
Background: Atherosclerosis leads high mortality, highlighting an urgent need for new therapeutic strategies. Protein kinases orchestrate multiple cellular events in atherosclerosis and may provide new therapeutic targets for atherosclerosis. Here, we identified a protein kinase, WEE1 G2 checkpoint ...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD050932 | Pride
Human 
ProteomicsMacrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates worldwide. Doublecortin-like kinase 1 (DCLK1), a microtubule-associated protein kinase, is involved in neurogenesis and human cancers. However, the role of DCLK1 in atherosclerosis remains undefined. In this st...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD039083 | Pride
Lc-ms/ms 
ProteomicsOTUD7B promotes cardiac hypertrophy by deubiquitinating SERCA2a
Cell samples were lysed in lysis buffer (8 M urea, 1% protease inhibitor cocktail). The supernatant was collected and the protein concentration was determined with BCA kit according to the manufacturer’s instructions. The peptides were obtained by digesting the protein with trypsin. Then, peptides w...
ORGANISM(S): Rattus Norvegicus 
2025-09-27 | PXD068918 |
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