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GenomicsA long noncoding RNA regulates sister chromatid cohesion
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81602 | biostudies-arrayexpress
Proteomicssin-lncRNA interactors in senescent fibroblasts MS
sin-lncRNA is a noncoding RNA molecule with a role in cellular senescence. In vitro RNA pulldown of biotynilated sin-lncRNA was performed to identify sin-lncRNA specific protein partners
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD044718 | Pride
Human fibroblasts Lncrna Ois Lc/ms/ms Senescence 
ProteomicsThe chromatin associated lncREST interacts with the replication fork to ensure effective replication stress response
In vivo pulldown of the long non-coding RNA lncREST combined with LC-MS/MS in HCT116 cells in non-treated and Hydroxyurea treated conditions
ORGANISM(S): Homo sapiens (Human) 
2024-01-02 | PXD043367 | Pride
Rna pulldown Hct116 Rbps 
TranscriptomicsA large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response
Recently, more than a thousand large intergenic non-coding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of ...
ORGANISM(S): Mus musculus 
2010-08-09 | E-GEOD-21761 | biostudies-arrayexpress
ProteomicsMass spectrometry and phosphorylation analysis of ORC1 protein, wild type or RNA-binding mutant (R441A, R444A and R465A), in GAA-RNA (RNA interactors of ORC1 identified by RIP-seq and iCLIP) knockdown or control conditions.
Mass spectrometry of wild type or mutant (RNA-binding) ORC1. Experiments were done in cellstransfected with a control ASO or an anti-GAA ASO, to knockdown RNA interactors of ORC1.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043232 | Pride
Phosphoproteomics of orc1 with altered protein rna-binding 
GenomicsA long noncoding RNA regulates sister chromatid cohesion [ChIP-seq]
Long noncoding RNAs (lncRNAs) have appeared to be involved in the most diverse cellular processes through multiple mechanisms. Here we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), transcriptionally activated by MYC, which is upregulated in multiple ca...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81600 | biostudies-arrayexpress
TranscriptomicsA long noncoding RNA regulates sister chromatid cohesion [microarray]
Long noncoding RNAs (lncRNAs) have appeared to be involved in the most diverse cellular processes through multiple mechanisms. Here we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), transcriptionally activated by MYC, which is upregulated in multiple ca...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81599 | biostudies-arrayexpress
TranscriptomicsA long noncoding RNA regulates sister chromatid cohesion [RNA-seq]
Long noncoding RNAs (lncRNAs) have appeared to be involved in the most diverse cellular processes through multiple mechanisms. Here we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), transcriptionally activated by MYC, which is upregulated in multiple ca...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81601 | biostudies-arrayexpress
TranscriptomicsPINT lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb Repressive Complex 2 (tissue)
It has been recently shown that the transcription factor p53 induces the expression of multiple lincRNAs. However, relatively little is known about the role that lincRNAs play in this pathway. Here we characterize a lincRNA named PINT (p53 Induced Noncoding Transcript). We show that PINT is a ubiqui...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-46271 | biostudies-arrayexpress
TranscriptomicsPINT lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb Repressive Complex 2 (MEF cells)
It has been recently shown that the transcription factor p53 induces the expression of multiple lincRNAs. However, relatively little is known about the role that lincRNAs play in this pathway. Here we characterize a lincRNA named PINT (p53 Induced Noncoding Transcript). We show that PINT is a ubiqui...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-46247 | biostudies-arrayexpress
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