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MetabolomicsCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as can...
2018-10-11 | MTBLS723 | MetaboLights
TranscriptomicsHigh Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas
In this study we investigated to which extend aberrant c Myc activity plays a functional role in other aNHL and whether it is independent from MYC translocations. Based on a combined microarray analysis of human germinal centre (GC) B cells transfected with c Myc and 220 aNHLs cases, we developed a ...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-31311 | biostudies-arrayexpress
UnknownPredicting input signals of transcription factors in Escherichia coli
Not available
S-SCDT-10_1038-S44320-025-00132-2 | biostudies-other
MetabolomicsGNPS - The nutritional and host environment shapes community ecology and keystone functions in a synthetic gut bacterial community
Microbe-microbe interactions are critical for gut microbiome function. A challenging task to understand health and disease-related microbiome signatures is to move beyond descriptive community-level profiling towards disentangling microbial interaction networks. Here, we aimed to determine members t...
ORGANISM(S): Bacteria (ncbitaxon:2) Mus Sp. (ncbitaxon:10095) 
2022-11-14 | MSV000090704 | GNPS
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
TranscriptomicsExpression profile of proliferating and differentiating primary human keratinocytes in vitro
Human epidermal keratinocytes undergo tightly controlled program of cell differentiation, leading to the formation of cornified envelope. Primary keratinocytes in vitro, under calcium stimulation mimic the differentiation program observed in vivo. Analysis of the transcription profile of two cell po...
ORGANISM(S): Homo sapiens 
2010-08-01 | E-GEOD-21413 | biostudies-arrayexpress
TranscriptomicsBL2 cells stimulated with B cell specific paracrine stimuli
Expression data of BL2 Burkitt Lymphoma cell line (controls and samples treated with different B cell specific stimuli) BL2 cells were cultured in RPMI and stimulated with the respective agents (rhCD40L, rhIL21, rhBAFF, LPS and antiIgM F(ab) fragments) for indicated timepoints. Cells were harvested ...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-42660 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression analysis of T-cell prolymphocytic leukemia (T-PLL) patient samples
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. To characterize the gene expression profiles, 12 T-PLL MNC samples (>90% tumor cell content) were scr...
ORGANISM(S): Homo sapiens 
2017-09-08 | E-MTAB-5916 | biostudies-arrayexpress
UnknownQuantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.
Not available
S-EPMC2801744 | biostudies-literature
UnknownHLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Not available
S-EPMC4702958 | biostudies-literature
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