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ProteomicsSmall-molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
RIPK2 mediates inflammatory signaling by the bacteria-sensing receptors NOD1 and NOD2, and inhibition of RIPK2 by kinase inhibitors is an emerging strategy to ameliorate NOD-mediated pathologies. However, the role for RIPK2’s kinase activity remains unclear. Here, we reveal that RIPK2 kinase activit...
ORGANISM(S): Homo sapiens (Human) 
2018-07-25 | PXD009724 | Pride
Ripk2 Chemical proteomics Ponatinib 
ProteomicsThermal proteome profilng of BMAL1 ligand CCM in U2OS cell lysate
The master transcription factor BMAL1-CLOCK is crucial for orchestrating rhythmic gene expression and governing circadian rhythms. Pharmacological manipulation of this central circadian regulator requires accessible protein cavities and selective compounds. By targeting BMAL1 through a resident cav...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD049298 | Pride
Thermal proteome profiling 
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