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ProteomicsLabel-free proteomic identification of proteins regulated by RIPK2 in PC3 cells
Label-free proteomics comparison of PC3 cells with versus without CRISPR/Cas9 knockout of RIPK2. The goal was to identify proteins downstream of RIPK2 in prostate cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2022-02-09 | PXD018890 | Pride
Ripk2 Proteomics Prostate cancer 
ProteomicsA new regulatory interface on RIPK2 controls XIAP binding and NOD signaling activity
Signaling via the intracellular pathogen receptors Nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2 requires Receptor Interacting Kinase 2 (RIPK2), an adaptor kinase that can be targeted for the treatment of various inflammatory diseases. However, the molecular mechanisms ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-13 | PXD017741 | Pride
Ripk2 Ubiquitination Xiap 
ProteomicsPhophoproteomic identification of kinases downstream of RIPK2
Identification of kinases whose activities are regulated by RIPK2 in prostate cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2022-02-09 | PXD018871 | Pride
Phosphoproteomics Kinases Ksea Ripk2 Prostate cancer 
TranscriptomicsTranscriptional profiles of PA1 teratoma cells transfected by RIPK1, RIPK2, RIPK3, or RIPK4
RIPK4 but not the related kinases RIPK1, RIPK2, and RIPK3 caused similar transcriptional changes to Wnt3a. PA1 cells were transfected by 8ug RIPK1, RIPK2, RIPK3, or RIPK4 for 48h, RNA were extracted and sequenced.
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-43362 | biostudies-arrayexpress
ProteomicsSmall-molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
RIPK2 mediates inflammatory signaling by the bacteria-sensing receptors NOD1 and NOD2, and inhibition of RIPK2 by kinase inhibitors is an emerging strategy to ameliorate NOD-mediated pathologies. However, the role for RIPK2’s kinase activity remains unclear. Here, we reveal that RIPK2 kinase activit...
ORGANISM(S): Homo sapiens (Human) 
2018-07-25 | PXD009724 | Pride
Ripk2 Chemical proteomics Ponatinib 
ProteomicsRIPK2 promotes colorectal cancer metastasis by protecting YAP degradation from ITCH-mediated ubiquitination
Colorectal cancer (CRC) is a leading cause of cancer death. RIPK2 is identified as a poor prognostic marker, promoting metastasis via bacterial invasion. High RIPK2-expressing tumor cells show enhanced invasiveness. This dataset comprises quantitative proteomic profiles of colorectal cancer (CRC) ce...
ORGANISM(S): Homo Sapiens 
2025-03-03 | PXD061372 |
ProteomicsProteomic identification of RIPK2 interactome
Identification of proteins associated with RIPK2 via immunoprecipitation-mass spectrometry (IP-MS)
ORGANISM(S): Homo sapiens (Human) 
2022-02-09 | PXD018870 | Pride
Proteomics Ripk2 Ip-ms Interactome 
TranscriptomicsRNA seq HT-29 wild type, IRGM depleted, or IRGM and RIPK2 depleted cells with Shigella flexneri
To understand the regulation of NODs-RIPK2 signaling during microbial infection
ORGANISM(S): Homo sapiens 
2022-09-16 | E-MTAB-12067 | biostudies-arrayexpress
GenomicsRIPK2-Regulated Gene Signature Associated with Poor Prognosis in Prostate Cancer
RIPK2-Regulated Gene Signature Associated with Poor Prognosis in Prostate Cancer
PRJNA1237822 | ENA
TranscriptomicsRIPK2-Regulated Gene Signature Associated with Poor Prognosis in Prostate Cancer
Receptor-interacting protein kinase 2 (RIPK2) has emerged as a promising drug target in various cancers, including prostate cancer (PC). However, the absence of reliable biomarkers to assess RIPK2 activity limits patient selection for anti-RIPK2 therapies and treatment monitoring. To address this ga...
ORGANISM(S): Homo sapiens 
2025-03-31 | GSE292278 | GEO
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