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TranscriptomicsDirect reprogramming of human fibroblasts to functional hepatocyte-like cells
Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic mar...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-42643 | biostudies-arrayexpress
TranscriptomicsConversion of mouse fibroblast to hepatocyte-like cells by defined factors
Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (Hnf1alpha, Gata4, and Foxa3) and p19Arf inactivation, tail-tip fibroblasts can be converted to hepatocyte-like (iHep) cells, exp...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-23635 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli
This SuperSeries is composed of the following subset Series: GSE39928: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [35MM] GSE39929: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [40MM] GSE39930: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [41MM] GSE39931: Muri...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39932 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [35MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39928 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [41MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39930 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [40MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39929 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [43MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39931 | biostudies-arrayexpress
TranscriptomicsmiR-27b synergizes with anticancer drugs
Drug resistance, caused by complex and redundant mechanisms, is a major obstacle in cancer treatment, especially in liver and kidney cancers. Combinational therapy of miRNAs, which concurrently target multiple pathways, with anticancer drugs represent a new strategy to improve the drug response. By ...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-53872 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic day 13.5 and 15.5 fetal livers lacking p38alpha, a mitogen-activated kinase that controls inflammatory responses and cell proliferation
The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional p38alpha alleles, we investigated its function in postnatal development and tumorigenesis. When p38alpha is specifically deleted in the mouse embryo, fetuses d...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7342 | biostudies-arrayexpress
ProteomicsQuantitative proteome profiling analyses on differential abdominal fat deposition between fat and lean chicken lines
Fat and lean broilers have similar body weight but acquire a divergent abdominal fat content
ORGANISM(S): Gallus Gallus 
2021-03-13 | PXD024710 |
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