Human acute promyelocytic leukemia cells

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1. Institut de Recherche en Immunologie et Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada. 2. Département de Biochimie et Biologie Moléculaire, Université de Montréal, Montréal, Québec, Canada. 3. Département de Chimie, Université de Montréal, Montréal, Québec, Canada (1)
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Cancer Research Institute, Beth Israel Deaconess Cancer Center Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. (1)
Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria. Joint Metabolome Facility, University of Vienna and Medical University of Vienna, Vienna, Austria. (1)
Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia Canada B3H4R2, Department of Pediatrics, Atlantic Research Centre, Dalhousie University, Halifax, Nova Scotia Canada B3H4R2 (1)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (1)
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Department of Proteomic Research and Mass Spectrometry, Laboratory of Systems Biology, IBMC, Moscow, Russia (1)
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Laboratory of Systems Biology,Institute of Biomedical Chemistry, Moscow, Russia (1)
Laboratory of systems biology, IBMC, Moscow, Russia (1)
Laboratory of systems biology,Institute of biomedical chemistry (IBMC), Moscow, Russia (1)
Proteomics and Cancer Cell Signaling Unit, German Cancer Research center(DKFZ), Heidelberg, Germany (1)
a) Centre de Recherche des Cordeliers (CRC), Université de Paris, Sorbonne Université, INSERM, Institut Universitaire de France, Paris, France. b) Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France. (1)
scientist EII , Rajiv Gandhi centre for Biotechnology (1)

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Gene expression profiling of pediatric acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is categorized as the M3 subtype in the French-American-British classification system. It represents a unique subtype of acute myeloid leukemia (AML) characterized by the t(15;17)/PML::RARA fusion, with leukemic cells arrested at the promyelocytic stage of myelopoi...

ORGANISM(S): Homo sapiens

2026-08-01 | E-MTAB-15773 | biostudies-arrayexpress

Methylation profiling of pediatric acute promyelocytic leukemia

ORGANISM(S): Homo sapiens

2026-08-01 | E-MTAB-15728 | biostudies-arrayexpress

Transcription profiling of human blood from acute promyelocytic leukemia patients using different differentiating agents

Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML). However, only the combinations of all-trans retinoic acid or arsenic trioxide with chemotherapy have been successful, and only in treating acute promyelocytic leukemia (also c...

ORGANISM(S): Homo sapiens

2010-03-23 | E-TABM-925 | biostudies-arrayexpress

PML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia

Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...

ORGANISM(S): Homo sapiens

2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress

DNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding (sequencing)

The origin of aberrant DNA methylation in cancer remains largely unknown. In this study, we elucidated the DNA methylome in primary Acute Promyelocytic Leukemia (APL) and the role of PML-RARa in establishing these patterns. APL patients showed increased genome-wide DNA methylation with higher variab...

ORGANISM(S): Homo sapiens

2012-11-08 | E-GEOD-42044 | biostudies-arrayexpress

Differential IFNa-stimulated gene expression profiles in PLZF-inducible U937T monocyte cells

Sensitivity to Interferon (IFN) is determined by a complex coordination of genetic and environmental factors. A previous experiment using two renal cancer cell lines differing markedly in their response to IFN were analyzed for their ISG profiles in order to determine gene expression changes associa...

ORGANISM(S): Homo sapiens

2010-05-18 | E-GEOD-16196 | biostudies-arrayexpress

L-Ascorbic acid and α-Tocopherol synergistically triggers apoptosis inducing antileukemic effects of arsenic trioxide via oxidative stress in human acute promyelocytic leukemia cells.

Chemosensitization is an effective strategy to overcome the drawbacks of arsenic trioxide (As2O3) treatment which may be possible through the use of dietary supplements in combination. Proteomic analysis revealed that the combination of arsenic trioxide with vitamins can alter a number of proteins r...

ORGANISM(S): Homo sapiens (Human)

2010-01-10 | PXD016771 | Pride

Lc- ms/ms Human acute promyelocytic leukemia cells

Transcription profiling of Acute Promyelocytic Leukemia samples from patients with wild type FLT3 or FLT3 mutations

In this series we described the gene expression profiles of 18 APL patients using a high density DNA-oligonucleotide microarray (Agilent) representing about 20.000 genes demonstrating the presence of a very uniform expression pattern of APL cases among which two mainly types of gene profiles were re...

ORGANISM(S): Homo sapiens

2008-05-07 | E-GEOD-2550 | biostudies-arrayexpress

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [ChIP-Seq]

All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...

ORGANISM(S): Homo sapiens

2012-03-14 | E-GEOD-34725 | biostudies-arrayexpress

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]

ORGANISM(S): Homo sapiens

2012-03-14 | E-GEOD-34672 | biostudies-arrayexpress

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