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MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
MetabolomicsUntargeted metabolomic analysis of human milk from healthy mothers reveals drivers of metabolite variability.
Understanding the human milk metabolome can help inform infant nutrition and health. Untargeted metabolomics was used to study breast milk from 31 healthy participants to assess the shared metabolites in milk from participants with various backgrounds and understand how different demographic, health...
2024-10-04 | MTBLS2419 | MetaboLights
UnknownPerfluoroalkyl substances and food allergies in adolescents.
Not available
S-EPMC8132312 | biostudies-literature
ProteomicsHuman-Soybean Allergies: Elucidation of the Seed Proteome & Comprehensive PPI Prediction
In this work, a total of eight proteins have been identified (six specific to the human proteome and two specific to the soybean proteome) that are supported by literature to be involved in human health, specifically related to immunological and neurological pathways. Our approach involved the use o...
ORGANISM(S): Glycine max 
2023-03-22 | PXD023875 | Pride
Human Ppi Pipe Allergy Seed protein Glycine max Ms/ms spectra Soybean Computational biology 
UnknownHuman Milk Metabolomics Are Related to Maternal Adiposity, Infant Growth Rate and Allergies: The Chinese Human Milk Project.
Not available
S-EPMC9144552 | biostudies-literature
Genomics
Antibody repertoires in patients with allergies
PRJNA391821 | ENA
TranscriptomicsAntigen specific human conventional T cells (CD154+) or regulatory T cells (CD137+) directed agains A. fumigatus or Birch pollen lysate isolated from Birch pollen allergic patients or healthy controls.
Foxp3+ regulatory T cells (Treg) play a central role for tolerance against self and innocuous environmental antigens. However, the role of antigen-specificity for Treg-mediated tolerance is only incompletely understood. Here we show by direct ex vivo characterization of human CD4+ T cells, that the ...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-77018 | biostudies-arrayexpress
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
ProteomicsProtein profiling of human serum against a panel of allergens.
Current diagnostics for allergies, such as skin prick and radioallergosorbent tests, do not allow for inexpensive, high-throughput screening of patients. Additionally, extracts used in these methods are made from washed pollen that lacks pollen surface materials that may contain allergens. We soug...
ORGANISM(S): Homo sapiens 
2010-09-08 | E-MTAB-177 | biostudies-arrayexpress
UnknownWheeze and Food Allergies in Children Born via Cesarean Delivery: The Upstate KIDS Study.
Not available
S-EPMC6357798 | biostudies-literature
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