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MetabolomicsUsing an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein
INTRODUCTION: The pathogenicity at differing points along the aggregation pathway of many fibril-forming proteins associated with neurodegenerative diseases is unclear. Understanding the effect of different aggregation states of these proteins on cellular processes is essential to enhance understand...
2018-06-11 | MTBLS455 | MetaboLights
ProteomicsPost-translational modifications of MSA alpha-synuclein
LC-MS/MS analysis of post-translational modifications in alpha-synuclein of five MSA cases.
ORGANISM(S): Homo Sapiens (human) 
2020-04-09 | PXD018434 | JPOST Repository
TranscriptomicsSingle-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons
The dataset consists of single-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons (10 weeks gestation) under six experimental conditions: Sample 1 – Control: Untreated cells. Sample 2 – PFF treated: Cells exposed to alpha-synuclein pre-formed fibrils (PFF) for 14 days. Sample 3...
ORGANISM(S): Homo sapiens 
2026-04-09 | E-MTAB-16863 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age.
Microarray comparison of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age. RNA was extracted from substantia nigral cells that were isolated by laser capture microdissection.
ORGANISM(S): Mus musculus 
2007-12-20 | E-MEXP-1383 | biostudies-arrayexpress
ProteomicsChemical Crosslinking of Isotopically Labeled α-Synuclein Reveals Structural Changes and the Interface of Oligomeric Species
Due to its high pharmaceutical relevance, α-synuclein is one of the best studied intrinsically disordered proteins to date. Its structural plasticity reaches from α-helical when bound to membranes through disordered in solution to β-sheet when forming amyloid fibrils. Recently the possible toxicity ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD027349 | Pride
Human Cross-linking mass spectrometry Α-synuclein 
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
TranscriptomicsMicroarray of five Caenorhabiditis elegans genotypes with or without a human alpha-synuclein transgene in the genetic background
Previous studies in Caenorhabditis elegans expressing the human alpha-synuclein protein, have shown that protein aggregation and some aetiologies of Parkinsons disease can be recapitulated in this model nematode. However, it is known that the genetic background is important in how the disease progre...
ORGANISM(S): Caenorhabditis elegans 
2019-02-11 | E-MTAB-6960 | biostudies-arrayexpress
TranscriptomicsaSyn polyA-RNAseq in PD and unaffected cortical brain samples
We sought to more precisely characterize the different alpha-synuclein (aSyn) 3M-bM-^@M-^YUTR mRNA species in normal and PD human brain. High-throughput, whole-transcriptome sequencing of the 3M-bM-^@M-^YUTR ends of polyadenylated mRNA transcripts (termed pA-RNAseq; see Methods) was performed on a ...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-GEOD-40710 | biostudies-arrayexpress
TranscriptomicsExpression data from Parkison's iPSCs with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30792 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of wild-type C. elegans (N2) fed with succinate (N2_Sc) against untreated control and transgenic C. elegans expressing human α-synuclein (NL5901)
Metabolites produced by human gut microbiome have a profound influence on brain health with increasing associations to Parkinson’s disease pathology that lack a mechanistic insight. Using Caenorhabditis elegans model expressing human α-synuclein, we systematically tested key microbial fermentation p...
ORGANISM(S): Caenorhabditis elegans 
2026-04-21 | E-MTAB-15794 | biostudies-arrayexpress
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