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TranscriptomicsTranscription profiling of human aortic smooth muscle cells exposed to hypoxia
Systemic arterial smooth muscle cells are exposed to a broad range of oxygen concentrations under physiological conditions. Hypoxia can modulate the proliferative response of smooth muscle cells leading to speculation about its role in vasculogenesis, vascular remodelling and the pathogenesis of ar...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4725 | biostudies-arrayexpress
TranscriptomicsStretch-dependent genes in vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-60447 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by EPIC microarray of human umbilical artery smooth muscle cells (HUASMCs) and human aortic smooth muscle cells (HAoSMCs)
Methylation profiling by EPIC microarray was performed on 3 human umbilical artery smooth muscle cells (HUASMCs) and human aortic smooth muscle cells (HAoSMCs) to assess CpG methylation in proximity to cardiovascular disease-associated variants.
ORGANISM(S): Homo sapiens 
2025-12-01 | E-MTAB-15426 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and Hey2 knockout mouse aortic smooth muscle cells treated with PDGF for different durations to identify differentially expressed transcripts.
The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expr...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6526 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human aortic vascular smooth muscle cells knocked down for FoxM1
Transcription factor FoxM1 is expressed in proliferating cells, and its expression is critical for cell proliferation in embryos and tumors. FoxM1 regulates a multi-gene transcriptional network for cell cycle regulation. We used microarrays to detail the global program of gene expression either dire...
ORGANISM(S): Homo sapiens 
2009-09-06 | E-GEOD-17543 | biostudies-arrayexpress
TranscriptomicsRNA Seq Transcriptomic profiling of PDGF-stimulated primary human aortic smooth muscle cells treated with ORAI1 inhibitor relative to controls
Platelet-derived growth factor (PDGF) signalling and the subsequent activation of the calcium ion channel, ORAI1 are critical drivers of pathological remodelling of native vascular smooth muscle cells to proliferative state, which is a process associated with various vascular diseases. This study ai...
ORGANISM(S): Homo sapiens 
2023-09-21 | E-MTAB-10955 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human aortic vascular smooth muscle cells treated with IL-17 or untreated
Investigate the effect of recombinant human IL-17A on vascular smooth muscle cells cultured from human aortas. Experiment Overall Design: SMCs from the aortas of three different donors were cultured in M199 media supplemented with 20% FCS and used at passage 3. The cells were either not treated or t...
ORGANISM(S): Homo sapiens 
2008-10-24 | E-GEOD-11367 | biostudies-arrayexpress
TranscriptomicsHuman aortic smooth muscle cells infected with different strains of Porphyromonas gingivalis
Human primary aortic smooth muscle cells were infected with wild type (W50, 381), W50 derived gingipain mutants (E8 and K1A), or 381 derived fimbriae mutants (DPG3 and KRX178) strains of Porphyromonas gingivalis for 24 hours. The RNA was extracted from the cells and human whole genome microarray wer...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-MTAB-3955 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat A7r5 vascular smooth muscle cells over-expressing glucose transporter
Hypothesis: Overexpression of the GLUT1 facilitative glucose transporter, in A7r5 vascular smooth muscle cells, is sufficient and/or necessary to induce alterations in gene expression which influence apoptosis, growth, and proliferation. Experiment Overall Design: Scientific Approach: A7r5 rat emb...
ORGANISM(S): Rattus norvegicus 
2009-11-07 | E-GEOD-15713 | biostudies-arrayexpress
TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-9490 | biostudies-arrayexpress
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