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BACKGROUND: Several studies have shown a correlation between an altered metabolome and respiratory allergies. The epithelial barrier hypothesis proposes that an epithelial barrier dysfunction can result in allergic diseases development. Der p 1 allergen from house dust mite is a...

2023-08-22 | MTBLS1755 | MetaboLights
Bronchial epithelial cells represent the first line of defense against invading airborne pathogens. They are important contributors to innate mucosal immunity and provide a variety of anti-microbial effectors. To investigate the role of epithelial cells upon infection of airway pathogens, we stimula...
ORGANISM(S): Homo sapiens 
mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in b...
ORGANISM(S): Homo sapiens 
Human bronchial epithelial cells were treated with vehicle (control), VOSO4 (V, 50 uM) or ZnSO4 (Zn, 50 uM) for 4 hours.
ORGANISM(S): Homo sapiens 
Human bronchial epithelial cells were stimulated without or with 100 ng/mL IL-13 for 24 hours.
ORGANISM(S): Homo sapiens 
The data set consists of 32 cytosolic samples of human bronchial epithelial cells that were collected during infection with S. aureus. The data include 8 (0h, 1h, 2.5 h, 6.5 h, 24 h, 48 h, 72 h, and 96 h post infection) time points that were collected out of four biological replicates. DIA data and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
Viral infections facilitate bacterial trafficking to the lower respiratory tract resulting in bacterial viral co infections. Bacterial dissemination to the lower respiratory tract is enhanced by influenza A virus induced epithelial cell damage and dysregulation of immune responses. Epithelial cells ...
ORGANISM(S): Homo Sapiens Staphylococcus Aureus Influenza A Virus (a/germany-by/74/2009(h1n1)) Streptococcus Pyogenes 
2022-06-13 | PXD026625 | panorama
Human Rhinovirus (HRV) infection can trigger exacerbations of asthma. Understanding of the mechanisms provoking airway inflammation and remodeling in asthma, as well as the pathogenic mechanisms of HRV infection and its association with asthma exacerbations, may offer significant opportunities for i...
ORGANISM(S): Homo sapiens 
Intercellular communication is important for host immunity in response to bacterial infections. Nontuberculous mycobacterium (NTM), such as Mycobacterium abscessus (M.ab), is a group of environmental bacteria that can cause severe lung infections in individuals with pre-existing lung conditions, inc...
ORGANISM(S): Homo sapiens (Human) Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) 
2026-03-30 | PXD056025 | Pride
RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone.
ORGANISM(S): Homo sapiens 
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