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MetabolomicsFatty acid synthesis in colorectal cancer: characterization of lipid metabolism in serum, tumour, and normal host tissues
The objective of the experiment was to compare serum fatty acid metabolite abundance between individuals with varying clinical stages of colorectal cancer (stage I-IV) and age-and-gender matched disease-free controls. Fatty acid metabolite abundance was compared between locoregional (stage I-III) an...
2016-12-15 | MTBLS27 | MetaboLights
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
TranscriptomicsColon tumor samples
In response to polarization cues, cultured Caco-2 cells, a human colon adenocarcinoma-derived cell line, form a polarized epithelium resembling normal enterocytes. We investigated potential signaling mechanisms activated by Caco-2 cells that might trigger the genome-wide transcriptional reprogrammi...
ORGANISM(S): Homo sapiens 
2007-08-17 | E-GEOD-7466 | biostudies-arrayexpress
TranscriptomicsAll exon array expression data in normal colon and primary colon cancer lines [expression]
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, despite the fact that distal regulatory elements play a central role in controlling transcription patterns. Here we utilize the histone mark H3K4me1 to analyze gain and loss of en...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36400 | biostudies-arrayexpress
TranscriptomicsThe prognostic and predictive value of a six-microRNA-based classifier in stage II colon cancer
microRNA profiling of colon tumor tissues vs adjacent normal tissues 40 paired tumor and adjacent normal tissues of stage M-bM-^EM-! colon caner
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-49246 | biostudies-arrayexpress
TranscriptomicsExpression patterns of cancer-related genes and their putative antisense transcripts in normal and colon cancer tissues
Background: Recent studies have identified thousands of sense-antisense gene pairs across different genomes by computational mapping of cDNA sequences. These studies have shown that approximately 25% of all transcriptional units in the human and mouse genomes are involved in cis-sense-antisense pair...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-14397 | biostudies-arrayexpress
TranscriptomicsTranscriptome of normal,paracancerous and cancerous colon tissues based on RNA-seq method
To support our research of colon cancer in human genome, we conducted massively parallel pyrosequencing of mRNAs (RNA-seq) using normal,paracancerouse and cancerous human colon tissues. We obtained a total of 29.9M reads from normal,33.0M reads from paracancerous and 36.5M reads from cancerous.The R...
ORGANISM(S): Homo sapiens 
2012-08-21 | E-GEOD-33782 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human normal pre-frontal cortex, liver, and colon tissues and colon tumors
DNA methylation, at CpG islands and promoters, is often inversely correlated with gene expression. We used expression microarrays to determine the relationship between DNA methylation and gene expression in 5 normal prefrontal cortex samples and 5 normal liver samples from the same individuals as we...
ORGANISM(S): Homo sapiens 
2009-01-23 | E-GEOD-13471 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in colorectal carcinoma samples compared to normal human colon
To globally define methylation-’prone’ and -’protected’ CpG islands in colorectal carcinoma we analyzed the methylation status of 23,000 CpG islands of the human genome in ten coleorectal carcinoma samples as well as normal colon using our previously described methyl-CpG immunoprecipitation ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17512 | biostudies-arrayexpress
TranscriptomicsExpression patterns of sense-antisense transcripts in normal and cancer tissues
We characterized the expression patterns of sense-antisense transcripts, based on available cDNA sequences, in colon (colorectal) cancer tissues and in normal tissues surrounding the cancer tissues. Although expression balances (ratios) of most of sense and antisense transcript pairs did not change ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-14398 | biostudies-arrayexpress
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