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Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
MetabolomicsThe functional role of OGDH for maintaining mitochondrial respiration and identity of primed human embryonic stem cells

Human embryonic stem cells (hESCs) can self-renew infinitely or differentiate into the 3 germ layer lineages in vitro with certain cues, holding great promise to model early human embryo development ex vivo. It is wildly accepted that hESCs take advantage of both glycolysis and ...

2022-03-03 | MTBLS4223 | MetaboLights
MetabolomicsStable isotope-resolved metabolomics of WT, GYG1 KO, and GYG2 KO human embryonic stem cells using 13C-labeled glucose and palmitate
Proper regulation of glycogen metabolism is fundamental to cellular energy homeostasis, and its disruption is associated with various metabolic disorders, including glycogen storage diseases (GSDs) and potentially diabetes. Despite glycogen’s role as an essential energy reservoir, the mechanisms gov...
2025-07-15 | MTBLS12586 | MetaboLights
TranscriptomicsExpression & polysome association in pluripotent human embryonic stem cells
The goal was to measure the expression and polysome association of genes with polysomes in human embryonic stem cells H9 human embryonic stem cells were kept in pluripotent conditions. Total RNA and polysome extracts were isolated.
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-31768 | biostudies-arrayexpress
GenomicsBiological insights from the whole genome sequences of human embryonic stem cell lines
Human embryonic stem cells (hESCs) are a powerful tool for the study of human development and can form the basis of cellular disease models or therapies. However, the genetic make-up and stability of hESCs has not been systematically studied at a genome-wide level with single nucleotide resolution. ...
EGAS00001002400 | EGA
ProteomicsMining Missing Protein Landscape in Subcellular Proteome of Human Embryonic Stem Cells
Human embryonic stem cells (hESCs) have capacity of self-renewal and multi-lineage differentiation into derivatives of three germ layers that are of clinical importance for regeneration medicine. Despite the significant progress of hESCs study for clinical application, factors responsible for mainta...
ORGANISM(S): Homo Sapiens (human) 
2019-05-20 | PXD009840 | JPOST Repository
TranscriptomicsMicroarray Expression Data from Haematopoietic Differentiated Human Embryonic Stem Cells
The underlying mechanisms which are responsible and govern early haematopoietic differentiation during development are poorly understood. Gene expression comparison between pluripotent human embryonic stem cells and earliest haematopoietic progenitors may reveal novel transcripts and pathways and p...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29115 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human astrocytes derived from trisomic human embryonic stem cells
Astrocytes derived from normal and aneuploid human embryonic stem cells, along with CCF-STTG1 astrocytoma cell line, and using three biological replicates for each sample, were used to develop an in-vitro model system, to identify biomarkers for astrocytic cancer cells and premalignant stem-like pro...
ORGANISM(S): Homo sapiens 
2010-06-01 | E-MEXP-2633 | biostudies-arrayexpress
TranscriptomicsArray-based comparative genomic hybridization study of human embryonic stem cell lines
G-banding of human embryonic stem cells (hESC) has proved their predisposition to aneuploidy of chromosomes 12, 17 and X. Now, using array-based comparative genomic hybridization, we find that hESC also accumulate other recurrent chromosomal abnormalities, such as duplications of stemness genes, sub...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-13422 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem cells and neuroepithelial cells
Comparing gene expressing profile of human embryonic stem cells and neuroepithelial cells differentiated from human embryonic stem cells.
ORGANISM(S): Homo sapiens 
2009-11-08 | E-MEXP-2426 | biostudies-arrayexpress
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