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TranscriptomicsSTRT RNAseq of human foreskin fibroblasts undergoing CRISPRa reprogramming
Comparison of human foreskin fibroblasts with different guide RNA compositions undergoing CRISPRa-mediated reprogramming. Cell samples have been collected at days 4, 8 and 12 of pluripotency induction. Each time point has three conditions with either (1) pluripotent reprogramming factor promoter tar...
ORGANISM(S): Homo sapiens 
2018-06-07 | E-MTAB-6186 | biostudies-arrayexpress
GenomicsSTRT RNAseq of human foreskin fibroblasts undergoing CRISPRa reprogramming
STRT RNAseq of human foreskin fibroblasts undergoing CRISPRa reprogramming
PRJEB23472 | ENA
TranscriptomicsSenescent and myofibroblastic cancer-associated fibroblasts share a contractile phenotype regulated by NOX4 generation of reactive oxygen species in the tumour microenvironment
Cancer associated fibroblasts characterized by an myofibroblastic phenotype play a major role in the tumour microenvironment, being associated with poor prognosis. We found that this cell population is made in part by senescent fibroblasts in vivo. As senescent fibroblasts and myofibroblasts have be...
ORGANISM(S): Homo sapiens 
2017-06-01 | E-MTAB-3101 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human foreskin fibroblasts grown as multicellular spheroids or as a monolayer
Human foreskin fibroblasts grown as multicellular spheroids or as a monolayer
ORGANISM(S): Homo sapiens 
2009-12-30 | E-MEXP-1226 | biostudies-arrayexpress
TranscriptomicsA comparison of gene expression between human dermal fibroblasts and neurons infected by varicella zoster virus
The cellular transcriptomes of VZV-infected fibroblasts and T-lymphocytes have been reported, but not that of human neurons. In order to determine the transcriptional response of human neurons to VZV infection, we generated 95%-pure populations of neurons from hESC, infected them with recombinant GF...
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-54385 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of immediate early events in mRNA-mediated cellular reprogramming of human foreskin fibroblasts
In this study human neonatal foreskin fibroblasts (HFF1 and BJ) were lipofected with an equal mixture of human reprogramming factor-encoding mRNAs. The cells were lysed and total RNA was harvested 24 hours post-transfection. Gene regulation was evaluated with respect to corresponding mock-transfecte...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-34943 | biostudies-arrayexpress
TranscriptomicsChIP-chip of siGFP- or siHOTAIR-treated foreskin fibroblasts with anti-LSD1 or anti-SUZ12 antibodies on human HG18 Nimblegen promoter arrays
Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic inheritance. Here we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct histone modification complexes. A 5’ domain of HOTAIR binds Polycomb Repressive Complex 2 (PRC2) while a 3’ domain of H...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22344 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human foreskin fibroblasts cultured in media supplemented with human sera
Treatment of cultured cells with serum collected from humans on long-term calorie restriction enhances stress resistance in vitro. RNA expression was compared in human foreskin fibroblasts cultured in media supplemented with human sera obtained from: 1) healthy lean and weight-stable volunteers who ...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-GEOD-41790 | biostudies-arrayexpress
MetabolomicsHuman Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism
Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential to i...
2020-06-26 | MTBLS1073 | MetaboLights
TranscriptomicsGene expression profile of cardiomyocyte-like cells derived from human foreskin and lung fibroblasts, and human ES cell-derived cardiomyocytes
Cardiomyocyte-like cells can be reprogrammed from somatic fibroblasts by combinations of genes, providing a new avenue for cardiac regenerative therapy. Here we show that functional cardiomyocytes can be rapidly and efficiently generated from human fibroblasts by specific combination small molecules...
ORGANISM(S): Homo sapiens 
2014-03-13 | E-GEOD-55820 | biostudies-arrayexpress
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