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MetabolomicsUntargeted metabolomics as a hypothesis-generation tool in plant protection product discovery: Highlighting the potential of trehalose and glycerol metabolism of fungal conidiospores as novel targets

INTRODUCTION: The production of high quality and safe food represents a main priority for the agri-food sector in the effort to sustain the exponentially growing human population. Nonetheless, there are major challenges that require the discovery of new, alternative, and improved...

2020-09-08 | MTBLS1565 | MetaboLights
MetabolomicsDifferential alteration of plant functions by homologous fungal candidate effectors

Rust fungi are plant pathogens that cause epidemics which threatens the production of many important plant species, such as wheat, soy, coffee and poplar. Melampsora larici-populina (Mlp) causes the poplar rust and encodes at least 1184 candidate effectors (CEs), however their functions are poorl...

2020-12-03 | MTBLS2096 | MetaboLights
MetabolomicsPlant elicitor peptide signalling confers rice resistance to piercing-sucking insect herbivores and pathogens
Rice is a staple food crop worldwide, and its production is severely threatened by phloem-feeding insect herbivores, particularly the brown planthopper (BPH, Nilaparvata lugens), and destructive pathogens. Despite the identification of many BPH resistance genes, the molecular basis of rice resistanc...
2022-02-23 | MTBLS3518 | MetaboLights
MetabolomicsTargeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence
There is an urgent need to develop novel antifungals to tackle the threat that fungal pathogens pose to human health. In this work, we have performed a thorough characterisation and validation of the promising target methionine synthase. We have uncovered that in Aspergillus fumigatus the absence of...
2020-10-15 | MTBLS1636 | MetaboLights
ProteomicsIn-depth evaluation of the acetylome in major human fungal pathogens elucidates the essential role of lysine acetylation in regulation of fungal pathogenicity
Fungal pathogens cause deadly diseases in living organisms. Numerous studies suggest that lysine acetylation is a critical regulator in pathogenic fungi, but an in-depth and cross-species analysis of the acetylome in major pathogenic fungi is lacking, and our knowledge of the mechanism of acetylatio...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2019-04-29 | PXD010354 | Pride
Cryptococcus neoformans Virulence Protein posttranslational modification Human fungal pathogens Acetylation 
TranscriptomicsRNA-Seq of healthy human dendritic cells after challenge with four different fungal pathogens, and of four fungal pathogens after challenge with healthy human dendritic cells, SYBARIS project.
Dendritic cells from three healthy human donors were cultured in the presence or absence of either Aspergillus fumigatus, Saccharomyces cerevisiae, Candida albicans or Candida parapsilosis. Each of the four fungi were also cultured in the absence of human cells. RNA-sequencing was used to evaluate d...
ORGANISM(S): Homo sapiens + Candida albicans 
2016-04-30 | E-SYBR-2 | biostudies-arrayexpress
UnknownAn evolutionary perspective on zinc uptake by human fungal pathogens.
Not available
S-EPMC4433550 | biostudies-literature
TranscriptomicsDissecting the root-fungal interface in 3D reveals spatial-distinct signalling landscapes
This submission comprises all raw sequencing reads generated and/or utilised in the analyses presented in the associated manuscript. The dataset comprises two independent experimental datasets, each designed to address distinct biological questions regarding the transcriptional behaviour of Fusarium...
ORGANISM(S): Fusarium oxysporum 
2026-08-14 | E-MTAB-17442 | biostudies-arrayexpress
UnknownPersister cells in human fungal pathogens.
Not available
S-EPMC12548908 | biostudies-literature
TranscriptomicsMilbemycins: more than efflux inhibitors for fungal pathogens
This study investigated the effect of milbemycons as efflux inhibitors and antifungal agents. Milbemycin oxims can inhibit growth of Candida glabrata and C. albicans. The effect of milbemycins on transcriptomes was inbvestigated. Gene expression was measured in C. glabrata milbemycin-treated cells (...
ORGANISM(S): Candida albicans 
2013-03-08 | E-GEOD-40232 | biostudies-arrayexpress
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