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TranscriptomicsExpression profiling of human adipose tissue derived stem cells cultured at various oxygen tensions
Adipose tissue is a plentiful and easily accessible source of mesenchymal stem cells that have been shown to be multi potent and possibly have immuno suppressive capacity(Zuk, Zhu et al. 2002; McIntosh, Zvonic et al. 2006; Prichard, Reichert et al. 2008). Several studies have identified hypoxia and ...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-12884 | biostudies-arrayexpress
ProteomicsProteome analysis of adipose-derived stem cells cultured under clinically relevant conditions in a wound healing perspective
There is a large body of evidence supporting the beneficial role of adipose-derived stem cells (ASCs) in tissue repair and regeneration. These effects appear to be mainly mediated by paracrine signaling pathways and enhanced during hypoxia. Mass spectrometry (MS) represents a valuable tool for prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080858 | MassIVE
ProteomicsThe effects of mild intermittent hypoxia exposure on the abdominal subcutaneous adipose tissue proteome in overweight and obese men: A first-in-human randomized, single-blind, cross-over study
Adipose tissue (AT) oxygen tension (pO2) has been implicated in AT dysfunction and metabolic perturbations in both rodents and humans. Compelling evidence suggests that hypoxia exposure alters metabolism, at least partly through effects on AT. However, it remains to be elucidated whether mild interm...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD029213 | Pride
Human hypoxia adipose tissue 
TranscriptomicsHypoxia-induced modulation of gene expression in human adipocytes - A microarray study
Obesity is characterised by expansion of white adipose tissue, accompanied by an inflamatory response. It has been proposed that the inflammatory state observed may be linked to relative hypoxia in clusters of adipocytes distant from vasculature. Adipose tissue hypoxia has been observed in both an...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-34007 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human adipose-derived mesenchymal stem cells cultured in hypoxia against normoxia controls, and human tympanic membrane keratinocytes
Human adipose-derived mesenchymal stem cells were cultured either in hypoxia (Hx; <0.1% oxygen) or standard culture conditions (normoxia, Nx) over 48 hours in serum-free medium. Human tympanic membrane keratinocytes were cultured in standard culture conditions over 48 hours in serum-free medium.
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-9979 | biostudies-arrayexpress
TranscriptomicsIsolation and Characterization of a Novel Population of Pluripotent Stem Cells Derived from Human Adipose Tissue
Transcriptional comparison of two subpopulations of stem cells isolated from lipoaspirated human adipose tissue, profiling Adipose Stem Cells (ASCs) and Multilineage Differentiating Stress-Enduring Adipose Tissue cells (MUSE-ATs). Experiments focused in the isolation and characterization of a new po...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-46353 | biostudies-arrayexpress
GenomicsComprehensive analysis of different in vitro insulin resistance models
Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety of treatments, but what aspects of the in vivo responses are captured by these models remains unknown. W...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-35724 | biostudies-arrayexpress
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
UnknownHypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells.
Not available
S-EPMC3159546 | biostudies-literature
GenomicsGene expression in human adipose tissue derived stromal cells (ADSC) after exposure to hypoxia
Gene expression in human adipose tissue derived stromal cells (ADSC) after exposure to hypoxia
PRJNA539977 | ENA
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