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MetabolomicsDIVA Metabolomics: Differentiating Vaccination Status Following Viral Challenge Using Metabolomic Profiles
This study employed metabolomic profiling technologies, to identify metabolites (small molecules) in blood which are found at different levels in vaccinated compared to non-vaccinated animals exposed to virus.
2018-07-13 | MTBLS456 | MetaboLights
MetabolomicsFecal metabolic changes in mice before Salmonella infection
With the monophasic variant of Salmonella Typhimurium (S. 4,[5],12:i-) emerging as one of the most prevalent serotypes, multidrug resistance has become an increasingly serious clinical challenge. Conventional antibiotic therapy is further constrained by adverse effects, including resistance selectio...
2026-10-04 | MTBLS15911 | MetaboLights
TranscriptomicsGene expression signatures of symptomatic respiratory viral infection in adults
Diagnosis of acute respiratory viral infection is currently based on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis. We used microarrays to capture p...
ORGANISM(S): Homo sapiens 
2009-08-06 | E-GEOD-17156 | biostudies-arrayexpress
TranscriptomicsRNA-seq of longitudinal human blood and nose swab samples from a controlled human infection experiment with SARS-CoV-2 virus
Controlled human infection experiments enable longitudinal profiling of immune responses to a pathogen. 36 healthy volunteers aged 18-29 years, with no evidence of previous infection or vaccination, were inoculated with SARS-CoV-2 virus and quarantined for 14 days. Blood samples for RNA sequencing w...
ORGANISM(S): Homo sapiens 
2024-04-08 | E-MTAB-12993 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling facilitates classification of response to influenza challenge
Despite increases in vaccination coverage, reductions in influenza-related mortality have not been observed. Better vaccines are therefore required and influenza challenge studies can be used to test the efficacy of new vaccines. However, this requires the accurate post-challenge classification of s...
ORGANISM(S): Homo sapiens 
2014-11-06 | E-GEOD-61754 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection
Background: The mosquito Anopheles gambiae is a major vector of human malaria. Increasing evidence indicates that blood cells (hemocytes) comprise an essential arm of the mosquito innate immune response against both bacteria and malaria parasites. To further characterize the role of hemocytes in mos...
ORGANISM(S): Anopheles gambiae 
2011-10-31 | E-GEOD-33269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelial cells before and after segmental allergen challenge to identify effects of allergen challenge on airway epithelial cell gene expression
Allergen exposure induces the airway epithelium to produce chemoattractants, proallergic interleukins, matrix-modifying proteins, and proteins that influence the growth and activation state of airway structural cells. These proteins, in turn, contribute to the influx of inflammatory cells and change...
ORGANISM(S): Homo sapiens 
2007-11-21 | E-GEOD-3004 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human bronchoalveolar lavage and lung biopsy samples in the segmental endotoxin challenge model
Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy can be used as a model to safely induce transient airway inflammation in the human lung. The LPS challenge model enables investigation of cellular mechanisms involved in pulmonary inflammatory processes as well as pharmacodynamic ana...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-13318 | biostudies-arrayexpress
TranscriptomicsAbsence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge
To further investigate the underlying mechanisms of severe acute respiratory syndrome (SARS) pathogenesis and evaluate the therapeutic efficacy of potential drugs and vaccines it is necessary to use an animal model that is highly representative of the human condition in terms of respiratory anatomy,...
ORGANISM(S): Mustela putorius furo 
2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of M. tuberculosis H37Rv infecting macrophage-like THP-1 cells during 48h
Transcriptional changes during early infection of macrophage-like THP-1 cell line with pathogenic bacterium Mycobacterium tuberculosis. RNAseq samples were taken at 0h (THP-1 cells growing in the RPMI medium), and after 4h, 24h and 48h post infection. Bacterial enrichment was performed to increase t...
ORGANISM(S): Homo sapiens 
2017-08-01 | E-MTAB-5287 | biostudies-arrayexpress
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