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TranscriptomicsExpression profiling of skin fibroblast, iPSC, iPSC-derived neural progenitors, and iPSC-derived neurons from Autism Spectrum Disorder male patients and their unaffected normal male siblings
Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder, which is characterized by disturbances of brain function and behavioral deficits in core areas of impaired reciprocal socialization, impairment in communication skills, and repetitive or restrictive interests and behaviors...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-65106 | biostudies-arrayexpress
TranscriptomicsHuman iPSC-based Modeling of Late-Onset Disease using Progerin-induced Aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) sets their identity back to an embryonic age. This presents a fundamental hurdle for modeling late-onset disorders using iPSC-derived cells. We therefore developed a strategy to induce age-like features in multiple iPSC-derived li...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-52431 | biostudies-arrayexpress
ProteomicsDevelopment and Comparative Evaluation of Endolysosomal Proximity Labeling-based Proteomic Methods in Human iPSC-derived Neurons
Proximity-based in situ labeling techniques offer a unique way to capture both stable and transient protein-protein and protein-organelle interactions. Combining this technology with mass spectrometry (MS)-based proteomics allows us to obtain snapshots of molecular microenvironments with nanometer r...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-10 | MSV000086260 | MassIVE
Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
MetabolomicsNeurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Exposure to solvents may contribute to the development of neurodevelopmental and neurodegenerative diseases. Glycol ethers consist in a widely used class of organic solvents leading to workers and consumers exposure via many different applications. Ethylene glycol ethers are gradually being repla...

2026-08-25 | MTBLS12921 | MetaboLights
MetabolomicsNeurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Exposure to solvents may contribute to the development of neurodevelopmental and neurodegenerative diseases. Glycol ethers consist in a widely used class of organic solvents leading to workers and consumers exposure via many different applications. Ethylene glycol ethers are gradually being repla...

2026-08-25 | MTBLS12771 | MetaboLights
TranscriptomicsHuman iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Control (CRL2429 C11) and A-T (MC3/AT30) iPSC were differentiated according to Erceg et al to generate cerebellar precursors Examination of changes in gene expression after a 34 day differentiation protocol in control and A-T iPSC
ORGANISM(S): Homo sapiens 
2017-10-02 | E-GEOD-75852 | biostudies-arrayexpress
TranscriptomicsGenetic variability exceeds cell-type memory and determines iPSCs differentiation potential-implications for biobanking
Summary To address the issue of retention of somatic cell memory in iPSCs we compared gene expressions of genetically matched human iPSCs derived from fibroblasts and blood. We were using the all-in-one type footprint free SeVdp-iPS system, for generation of uniform iPSC lines Our results show that...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-MTAB-3825 | biostudies-arrayexpress
TranscriptomicsExpression data from of HD-iPSC and CON-iPSC neuron derivatives
Compared the global gene expression profiles of HD- and CON-iPSC-derived neurons We used microarrays to detail the global programme of gene expression for comparing the global gene expression profiles of HD- and CON-iPSC-derived neurons and facilitating studies of medium spiny neurons (MSN)-degenera...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-59051 | biostudies-arrayexpress
ProteomicsCentrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons
Local microtubule remodeling is critical for axon formation, the first step in establishing neuronal polarity. However, the function of the microtubule organizing centrosomes during the onset of axon formation, is still under debate. Here, we demonstrate that centrosomes play an essential role in co...
ORGANISM(S): Homo sapiens (Human) 
2021-02-12 | PXD020221 | Pride
Centrosome  axon  development  human  hipsc-derived neuron 
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