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MetabolomicsNon-invasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer
Lung cancer remains the most common cause of cancer deaths worldwide, yet there is currently a lack of diagnostic noninvasive biomarkers that could guide treatment decisions. Small molecules (<1500 Da) were measured in urine collected from 469 lung cancer patients and 536 population controls using u...
2014-05-06 | MTBLS28 | MetaboLights
MetabolomicsDistinct metabolic profiles in lung adenocarcinomas presenting as solid or ground-glass opacities

Metabolomic profiling provides real-time insights into tissue physiology and upstream molecular events. Despite its potential in cancer research, large-scale integrative studies in lung adenocarcinoma (LUAD) remain scarce. We analyzed 262 tissue samples from 165 LUAD patients using metabolomic, t...

2025-12-23 | MTBLS13565 | MetaboLights
ProteomicsLung cancer and Normal Lung Tissue LC-MS/MS
The Chromosome-centric Human Proteome Project (C-HPP) was recently initiated as an international collaborative effort. Our team adopted chromosome 9 (Chr 9) and performed a bioinformatics and proteogenomic analysis to catalog Chr 9-encoded proteins from normal tissues, lung cancer cell lines and lun...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083969 | MassIVE
TranscriptomicsGene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients
Tumor microenvironment plays an important role in regulating cell growth and metastasis. Recently we developed an ex vivo lung cancer model (4D) that forms perfusable tumor nodules on a lung matrix that mimics human lung cancer histopathology and protease secretion pattern. We compared the gene ex...
ORGANISM(S): Homo sapiens 
2013-09-16 | E-GEOD-45142 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of normal lung tissue samples
Genome wide DNA methylation profiling of normal lung tissue samples. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in nor mal lung tissue samples. Samples included 244 normal lung tissue samples from lung cance...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-52401 | biostudies-arrayexpress
TranscriptomicsNon-small-cell lung tumor and normal lung tissue methylation
Using paired tumor and non-tumor lung tissues from 47 individuals we identified common changes in DNA methylation associated with the development of non-small cell lung cancer. Pathologically normal lung tissue taken at the time of cancer resection was matched to tumorous lung tissue and together we...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-27902 | biostudies-arrayexpress
MetabolomicsThe Metabolic Fate of Oxaliplatin in the Biological Milieu Investigated During In Vivo Lung Perfusion Using a Unique Miniaturized Sampling Approach Based on Solid-Phase Microextraction Coupled with Liquid Chromatography-Mass Spectrometry

Adjuvant chemotherapy after pulmonary metastasectomy for colorectal cancer may reduce recurrence and improve survival rates; however, the benefits of this treatment are limited by the significant side effects that accompany it. The development of a novel in vivo lung perf...

2022-08-02 | MTBLS4982 | MetaboLights
TranscriptomicsEstablishment and Comparative Characterization of Novel Non-Small Cell Lung Cancer Cell Lines and Their Corresponding Tumor Tissue
Cell lines play an important role for studying tumor biology and novel therapeutic agents. We demonstrated that cell lines represent a useful and reliable in vitro system for studying basic mechanisms in lung cancer. Moreover, we presented 3 novel, comprehensively characterized SCC cell lines. Estab...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-25251 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer
Despite surgical treatment of stage I non-small cell lung cancer (NSCLC), one third of patients will eventually have a recurrence. Robust prognostic markers are required to better manage therapy options. MicroRNAs play important roles in human cancers. The purpose of this study is to identify miRNA ...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-29135 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling analysis of bone metastases of human non-small cell lung cancer (NSCLC) in mice
Using a multiorgan metastasis model of human NSCLC cells (ACC-LC319/bone2) in NK cell-depleted SCID mice, we attempted to identify genes involved in the organ-selective nature of lung cancer-metastasis process, especially bone metastasis. Genome-wide gene expression profile of 15 metastatic lesions ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-29391 | biostudies-arrayexpress
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