Sort   by:  
 Page size 
ProteomicsDDX3X interactome - The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading
As DDX3X can regulate Rac1 levels, cell motility and metastasis, we have examined DDX3X protein interactions and localisation using a number of complementary approaches.
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006497 | Pride
Human mrc5 q-exactive mass spectrometer (lc-ms) 
ProteomicsParadoxical drug sensitization of lung cancer cells by stromal fibroblast-secreted IGF-binding proteins: Secretomics
Cancer-associated fibroblasts (CAFs) are an integral part of the tumor microenvironment often linked to drug resistance. Here, we report that CAFs, but not normal fibroblasts, can promote either resistance or unexpected drug sensitization of different lung cancer cells. Using unbiased secretomics, t...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD023626 | Pride
Lung cancer Secretomics Fibroblasts Targeted therapy 
Sort   by:  
 Page size