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TranscriptomicsTranscription profiling of human adipose tissue using an expanded patient cohort
Obesity is a risk factor for numerous metabolic disorders; however, not all obese individuals are prone to insulin resistance. The central aim of this study was to identify molecular pathways directly related to insulin resistance independent of BMI in obesity. We sought to determine the gene expre...
ORGANISM(S): Homo sapiens 
2010-04-07 | E-GEOD-20950 | biostudies-arrayexpress
TranscriptomicsFKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance.
Glucocorticoid excess is linked to central obesity, adipose tissue insulin resistance and type 2 diabetes mellitus. The aim of our study was to investigate the effects of dexamethasone on gene expression in human subcutaneous and omental adipose tissue, in order to identify potential novel mechanism...
ORGANISM(S): Homo sapiens 
2014-08-18 | E-GEOD-42902 | biostudies-arrayexpress
GenomicsComprehensive analysis of different in vitro insulin resistance models
Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety of treatments, but what aspects of the in vivo responses are captured by these models remains unknown. W...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-35724 | biostudies-arrayexpress
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
TranscriptomicsCD1d-restricted NKT cell function prevents insulin resistance in lean mice, and is regulated by adipocytes and is regulated by adipocytes
Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased i...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-39534 | biostudies-arrayexpress
TranscriptomicsIndividualized analysis of subcutaneous and omental abdominal adipose tissue from non-obese and obese subjects
Individualized analysis through expression profiling of 20,000 probes in 28 tissue samples evaluated in subcutaneous and omental adipose tissue obtained during surgical intervention in non-obese and obese patients. Patients consisted of men and women of varying body size (lean to severely obese). Sa...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15524 | biostudies-arrayexpress
ProteomicsHuman adipose insulin resistance
Adipocytes play a major role in whole body fuel homeostasis. Integrated proteomic analysis of adipose from insulin resistant versus healthy humans or mice or in 3T3-L1 adipocytes revealed defects in the mevalonate/coenzyme Q (CoQ) biosynthesis pathway as a unifying feature of adipocyte insulin resis...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD006891 | Pride
Human obese adipose tissue insulin resistance 
TranscriptomicsThe effects of moderate weight gain in adipose tissue gene expression in metabolically-normal (MNO) and metabolically-abnormal (MAO) subjects
Obesity is associated with insulin resistance and increased intrahepatic triglyceride (IHTG) content, which are key risk factors for diabetes and cardiovascular disease. However, a subset of obese people does not develop these metabolic complications. We tested the hypothesis that MNO, but not MAO, ...
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-62832 | biostudies-arrayexpress
TranscriptomicsAdipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity
This SuperSeries is composed of the following subset Series: GSE25401: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [gene expression] GSE25470: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [miRNA data] GSE25910: Adipose Tissue MicroRNAs as ...
ORGANISM(S): Homo sapiens 
2012-08-12 | E-GEOD-25402 | biostudies-arrayexpress
ProteomicsThe human diabetes-specific visceral adipose tissue proteome: insights into mechanisms of adipose tissue dysfunction in metabolic disease
Introduction: The human adipose tissue proteome associated with type 2 diabetes (DM) is not well described. An understanding of the DM-specific adipose tissue proteome would provide insight into mechanisms underlying the pathogenesis of DM. Methods: We used label-free proteomics analysis to quanti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-27 | MSV000085169 | MassIVE
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