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MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
MetabolomicsResolvin E1 in follicular fluid acts as a potential biomarker and improves oocyte developmental competence by optimizing cumulus cells

The metabolic profile of follicular fluid (FF) has been investigated to look for biomarkers for oocyte quality. Resolvin E1 (RvE1), a potent pro-resolving mediator, was reported to have protective action in cell function. The study aimed to examine the predictive value of RvE1 for oocyte quality ...

2020-03-26 | MTBLS1488 | MetaboLights
TranscriptomicsComparison of the human oocyte to its sister polar body
Clinicians need additional metrics for predicting quality of human oocytes for IVF procedures. Human polar bodies reflect the oocyte transcript profile. Quantitation of polar body mRNAs could allow for both oocyte ranking and embryo preferences in IVF applications. The transcriptome of a polar body ...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-32689 | biostudies-arrayexpress
ProteomicsHuman oocyte proteome and secretome
The proteome and secretome of human oocytes was studied by shotgun LCMSMS, starting from pools of 100 cells. Exploiting SP3, a novel technology for proteomic sample preparation using magnetic beads, we scaled down proteome analysis to single cells. Despite the low protein content of only ~100ng per...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-15 | MSV000088387 | MassIVE
TranscriptomicsLow dose human chorionic gonadotropin hCG
Influence of ovarian stimulation with 200 IU of hCG, (administered in the late follicular phase among ICSI patients undergoing a GnRH-antagonist protocol), on the endometrium on the day of oocyte pick-up. The purpose of the present study is to assess the influence of the administration of low dose h...
ORGANISM(S): Homo sapiens 
2010-10-02 | E-GEOD-18557 | biostudies-arrayexpress
TranscriptomicsTransciption profiling of human endometrial biopsies taken on the day of oocyte retrieval in stimulated IVF cycles with 1 or 2 embryos replaced on day 3 in the same cycle
In GnRH-antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression Experiment Overall Design: Endometrial biopsies taken on the day of oocyte retrieval in stimulated IVF cycles with 1 or 2 embryos replaced on day 3 in ...
ORGANISM(S): Homo sapiens 
2009-11-16 | E-GEOD-13027 | biostudies-arrayexpress
ProteomicsSingle-cell quantitative proteomic analysis of oocyte maturation revealed high heterogeneities in human in vitro matured oocytes
In this study we investigated the protein expression patterns during human oocyte in vitro and in vivo maturation (IVO) by single-cell quantitative proteomic analysis of 36 human oocytes. Among 2,094 proteins quantified in 34 oocytes (GV: 11 oocytes, IVM: 12 oocytes, IVO: 11 oocytes), 224 were diffe...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD023366 | Pride
Human oocyte maturation Single cell proteomics 
TranscriptomicsTranscription profiling of human oocytes
The identification of genes and deduced pathways from the mature human oocyte can help us better understand oogenesis, folliculogenesis, fertilization, and embryonic development. Human metaphase II oocytes were used within minutes after removal from the ovary, and its transcriptome was compared with...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12034 | biostudies-arrayexpress
TranscriptomicsGene expression in blastomeres after transfer of somatic cells into human oocytes
The exchange of the oocyte's genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cell types affected in degenerative human diseases. Such cells, carrying the patient's genome, might be useful for cell replacement. H...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-28022 | biostudies-arrayexpress
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