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MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
MetabolomicsNorgestrel exposure accelerated the abnormal occurrence of germinal vesicle breakdown and triggered damage to cellular structure and function in oocytes of the Pacific oyster (Crassostrea gigas)

Progestins are ubiquitous in aquatic environments, with adverse effects on aquatic organisms' reproduction even at extremely low concentrations (0.8 ng/L). As female germ cells, oocytes play an irreplaceable role in organismal reproductive processes. However, the toxic mechanism of norgestrel (NG...

2025-09-10 | MTBLS12976 | MetaboLights
TranscriptomicsHuman oocytes reprogram somatic cells to a pluripotent state
This SuperSeries is composed of the following subset Series: GSE27507: Gene expression in pluripotent stem cells derived after somatic cell genome transfer into human oocytes GSE28022: Gene expression in blastomeres after transfer of somatic cells into human oocytes Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-28024 | biostudies-arrayexpress
TranscriptomicsGene expression in blastomeres after transfer of somatic cells into human oocytes
The exchange of the oocyte's genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cell types affected in degenerative human diseases. Such cells, carrying the patient's genome, might be useful for cell replacement. H...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-28022 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human oocytes
The identification of genes and deduced pathways from the mature human oocyte can help us better understand oogenesis, folliculogenesis, fertilization, and embryonic development. Human metaphase II oocytes were used within minutes after removal from the ovary, and its transcriptome was compared with...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12034 | biostudies-arrayexpress
TranscriptomicsStorage time does not modify the gene expression profile of cryopreserved human metaphase II oocytes
Study question: Does storage time impact on transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? Summary answer: For the first time, we demonstrate that the length of cryostorage has no effect on the gene expression profile of human metaphase II oocytes. What is known alrea...
ORGANISM(S): Homo sapiens 
2015-09-19 | E-GEOD-69768 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mature oocytes in relation to age
Background: The development competence of human oocytes declines with increasing age. The objective of this study was to investigate the effect of age on gene expression profile in mature human oocytes.
Methods: mRNA was isolated for whole genome gene expression microarray analysis from metaphase...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MEXP-2347 | biostudies-arrayexpress
TranscriptomicsSmall RNA profiling of human cumulus cells and oocytes
Cumulus cells are biologically distinct from other follicular cells and perform specialized roles, transmitting signals within the ovary and supporting oocyte maturation during follicular development. The bi-directional communication between the oocyte and the surrounding cumulus cells is crucial fo...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-44792 | biostudies-arrayexpress
TranscriptomicsPiwi proteins and piRNAs in mammalian oocytes and early embryos
Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling evidence for strong Piwi-piRNA expression in oocytes of other mammals. Human fetal oocytes express PIWIL2 and transposon-enriched...
ORGANISM(S): Macaca fascicularis 
2015-03-27 | E-GEOD-64942 | biostudies-arrayexpress
ProteomicsHuman oocyte proteome and secretome
The proteome and secretome of human oocytes was studied by shotgun LCMSMS, starting from pools of 100 cells. Exploiting SP3, a novel technology for proteomic sample preparation using magnetic beads, we scaled down proteome analysis to single cells. Despite the low protein content of only ~100ng per ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD004142 | Pride
Human oocytes 
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