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TranscriptomicsDNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes
Little is known about the contribution of the epigenome to the pathophysiology of type 2 diabetes (T2D). Here we have used genome-wide DNA methylation profiling to obtain the first comprehensive DNA methylation data set for human T2D pancreatic islets. Therefore, we analyzed the methylation profile ...
ORGANISM(S): Homo sapiens 
2012-04-22 | E-GEOD-21232 | biostudies-arrayexpress
TranscriptomicsThe human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress
ProteomicsIdentification of HIPs in the islets of mice and non-diabetic human donors
Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD)...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-07 | PXD011606 | Pride
Hybrid insulin peptides (hips) Pancreatic islets 
GenomicsThe Pdx1 Cistrome of Pancreatic Islets
We performed global location analysis of Pdx1 occupancy in mouse and human islets.
ORGANISM(S): Mus musculus 
2012-05-23 | E-MTAB-1143 | biostudies-arrayexpress
GenomicsGlobal epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
Identifying cis-regulatory elements is important to understand how human pancreatic islets modulate gene expression in physiologic or pathophysiologic (e.g., diabetic) conditions. We conducted genome-wide analysis of DNase I hypersensitive sites, histone H3 lysine methylation marks (K4me1, K4me3, K7...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-23784 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human islets after in vitro expansion.
Pancreatic islet transplantation as a cure for type 1 diabetes (T1D) cannot be scaled up due to a scarcity of human pancreas donors. In vitro expansion of beta cells from mature human pancreatic islets provides an alternative source of insulin-producing cells. The exact nature of the expanded cells ...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-15543 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomics reveals unique features of human pancreatic islet cell subtypes
We report the single-cell RNA-seq based identification of 6 known human islet cell types (alpha cells, beta cells, delta cells, pp cells, acinar cells and duct cells) based on the expression of known marker genes. We further assess cell type specific gene expression and suggest novel marker genes fo...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-73727 | biostudies-arrayexpress
TranscriptomicsOpen chromatin in human pancreatic islets (FAIRE-seq) - Appendix to E-GEOD-17616
An appendix to the published Gaulton et al. work (PMID: 20118932; E-GEOD-17616). In the original paper, the authors note that samples 1 and 2 are not as pure as the third sample. This appendix provides FAIRE-Seq data obtained from a purified islet sample to replace the problematic published data. Th...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-MTAB-3199 | biostudies-arrayexpress
TranscriptomicsEpigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing and RNA sequencing analysis, we determined the epigenetic and transcriptional landscape of human pancreatic α, β, and exocrin...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50386 | biostudies-arrayexpress
TranscriptomicsMultiple Salivary Biomarkers for Early Detection of Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death. Lack of early detection technology for pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. Oral fluid (saliva) meets the demand for non-invasive, accessible, and highly efficie...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-14245 | biostudies-arrayexpress
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